TFPI2 and KLKB1

Data Source:
HPRD (in vitro)

		TFPI2	KLKB1
Description		tissue factor pathway inhibitor 2	kallikrein B1
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GO Annotations	Cellular Component	Extracellular Space Extracellular Matrix	Extracellular Region Extracellular Space Plasma Membrane Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent	Serine-type Endopeptidase Activity Protein Binding
	Biological Process	Blood Coagulation Negative Regulation Of Endopeptidase Activity	Factor XII Activation Proteolysis Blood Coagulation, Intrinsic Pathway Extracellular Matrix Disassembly Zymogen Activation Plasminogen Activation Fibrinolysis Positive Regulation Of Fibrinolysis
Pathways			Intrinsic Pathway of Fibrin Clot Formation Activation of Matrix Metalloproteinases Defective factor XII causes hereditary angioedema Defective SERPING1 causes hereditary angioedema
Drugs			Zinc Ecallantide Human C1-esterase inhibitor Conestat alfa Gabexate Zinc acetate Zinc chloride Zinc sulfate, unspecified form Lanadelumab Berotralstat
Diseases			Fletcher factor deficiency; Prekallikrein deficiency
GWAS		Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042)	Apolipoprotein A-IV levels ( 27412012) B-type natriuretic peptide levels ( 25561047) Blood metabolite levels ( 24816252) Blood protein levels ( 29875488 28240269) Cardiac troponin-I levels ( 31014085) Circulating chromogranin peptide levels ( 28011710) Circulating vasoactive peptide levels ( 23381795) Glycine levels ( 30837465) L-arginine levels ( 27656708) Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Obesity-related traits ( 23251661) Plasma renin activity levels ( 25477429) Response to statin therapy ( 20339536) Serum metabolite levels ( 24625756 23093944)
Interacting Genes		5 interacting genes: F11 KLKB1 PLG SKIL SMURF2	8 interacting genes: F12 HGF HGFAC IGFBP3 KNG1 MST1 SERPINA5 TFPI2
Entrez ID		7980	3818
HPRD ID		08962	01971
Ensembl ID		ENSG00000105825	ENSG00000164344
Uniprot IDs		P48307	A8K9A9 B4DMX2 E9PBC5 P03952
PDB IDs		1ZR0	2ANW 2ANY 4OGX 4OGY 5F8T 5F8X 5F8Z 5TJX 6I44 6O1G 6O1S 6T7P
Enriched GO Terms of Interacting Partners?
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