ARHGAP10 and PKN3

Data Source:
HPRD (in vitro)

		ARHGAP10	PKN3
Description		Rho GTPase activating protein 10	protein kinase N3
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm	Nucleus Golgi Apparatus Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activator Activity Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding
	Biological Process	Cytoskeleton Organization Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Protein Phosphorylation Signal Transduction Epithelial Cell Migration Peptidyl-serine Phosphorylation Intracellular Signal Transduction
Pathways		Rho GTPase cycle Regulation of PAK-2p34 activity by PS-GAP/RHG10	RHO GTPases activate PKNs
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737 29892015) Benign childhood epilepsy with centro-temporal spikes ( 32580138) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Immune reponse to smallpox (secreted IL-12p40) ( 22610502) QT interval ( 20031603) Resting heart rate ( 27798624)	Apolipoprotein B levels ( 32203549) Asthma ( 31361310) Axial length ( 24144296) Body mass index ( 26426971) Eating disorders (purging via substances) ( 23568457) Gamma glutamyl transferase levels ( 29403010) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Neutrophil count ( 32888494) Obesity-related traits ( 23251661) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) White blood cell count ( 32888494)
Interacting Genes		10 interacting genes: ANKS1A ARF6 CDC42 HRAS PAK2 PKN1 PKN3 RHOA SH3BP2 YWHAQ	9 interacting genes: ARHGAP10 ARHGAP26 GOLGA2 KRT31 MTUS2 PLD1 PNMA1 TFIP11 VPS52
Entrez ID		79658	29941
HPRD ID		07949	17856
Ensembl ID		ENSG00000071205	ENSG00000160447
Uniprot IDs		A0A2X0SFB3 A1A4S6	A0A024R8D6 Q6P5Z2
PDB IDs		2MIO
Enriched GO Terms of Interacting Partners?
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