PKN3 and ARHGAP10

Data Source:
HPRD (in vitro)

		PKN3	ARHGAP10
Description		protein kinase N3	Rho GTPase activating protein 10
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Golgi Apparatus Perinuclear Region Of Cytoplasm	Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding	GTPase Activator Activity Protein Binding
	Biological Process	Protein Phosphorylation Signal Transduction Epithelial Cell Migration Peptidyl-serine Phosphorylation Intracellular Signal Transduction	Cytoskeleton Organization Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		RHO GTPases activate PKNs	Rho GTPase cycle Regulation of PAK-2p34 activity by PS-GAP/RHG10
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Asthma ( 31361310) Axial length ( 24144296) Body mass index ( 26426971) Eating disorders (purging via substances) ( 23568457) Gamma glutamyl transferase levels ( 29403010) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Neutrophil count ( 32888494) Obesity-related traits ( 23251661) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) White blood cell count ( 32888494)	Atrial fibrillation ( 30061737 29892015) Benign childhood epilepsy with centro-temporal spikes ( 32580138) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Immune reponse to smallpox (secreted IL-12p40) ( 22610502) QT interval ( 20031603) Resting heart rate ( 27798624)
Interacting Genes		9 interacting genes: ARHGAP10 ARHGAP26 GOLGA2 KRT31 MTUS2 PLD1 PNMA1 TFIP11 VPS52	10 interacting genes: ANKS1A ARF6 CDC42 HRAS PAK2 PKN1 PKN3 RHOA SH3BP2 YWHAQ
Entrez ID		29941	79658
HPRD ID		17856	07949
Ensembl ID		ENSG00000160447	ENSG00000071205
Uniprot IDs		A0A024R8D6 Q6P5Z2	A0A2X0SFB3 A1A4S6
PDB IDs			2MIO
Enriched GO Terms of Interacting Partners?
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