MCPH1 and TRAP1

Data Source:
BioGRID (two hybrid)

		MCPH1	TRAP1
Description		microcephalin 1	TNF receptor associated protein 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Microtubule Organizing Center	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Membrane
	Molecular Function	Protein Binding Identical Protein Binding	RNA Binding Tumor Necrosis Factor Receptor Binding Protein Binding ATP Binding Protein Kinase Binding Unfolded Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Cerebral Cortex Development Regulation Of Kinase Activity Regulation Of Centrosome Cycle Regulation Of Inflammatory Response Bone Development Regulation Of Chromosome Condensation Protein Localization To Centrosome Mitotic Cell Cycle Arrest Neuronal Stem Cell Population Maintenance	Protein Folding Translational Attenuation Chaperone-mediated Protein Folding Negative Regulation Of Cellular Respiration Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide
Pathways		Condensation of Prophase Chromosomes	Respiratory electron transport
Drugs
Diseases		Primary microcephaly (MCPH)
GWAS		Alcoholic chronic pancreatitis ( 28754779) Birth weight ( 31043758) Carotid intima media thickness ( 30510157) Carotid intima media thickness (mean) ( 31801372) Cytomegalovirus antibody response ( 21993531) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Epirubicin-induced leukopenia ( 21799462) Estimated glomerular filtration rate ( 31152163) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Heel bone mineral density ( 30598549) Intraocular pressure ( 29785010) Metabolite levels ( 23823483) Post bronchodilator FEV1/FVC ratio ( 26634245) Venlafaxine response in generalised anxiety disorder (remitters vs non-remitters after 24 weeks) ( 28437668)	Asthma ( 32296059) Estimated glomerular filtration rate ( 31152163 31451708) Granulocyte count ( 27863252) Infliximab-induced mucosal healing in Crohn's disease ( 31039275) Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)
Interacting Genes		68 interacting genes: ABCC2 ACTG1 AKIP1 AKR7A2 ATM ATR B3GALT6 CCDC77 CCT5 CHEK1 COL1A1 COL27A1 COPB2 COPS3 CTSL DNAJA3 DNAJC19 EIF3F EIF4A2 EMG1 ENO1 FBLN1 FLNA GABARAPL2 HNRNPA2B1 HSPD1 KAT5 KDM1A LAMTOR5 LGALS3 MCM2 MCM5 MITD1 MRPL46 MT2A NCCRP1 NMI NR2F1 OBSL1 PHF11 PMVK POLD1 POLR2G PPA1 PPRC1 RACK1 RBM39 RSL24D1 RUVBL2 S100A16 SMARCB1 SMARCC2 SMOX SUPT6H TADA2A TAF1D THAP11 TPT1 TRAP1 TSEN54 UXT VIM WDR53 WDR61 WDR73 WDR75 WNT10B ZMIZ2	16 interacting genes: APP ESX1 EXT1 EXT2 HGS MCPH1 PSMC4 PTGER4 RB1 SMAD4 TGFBR1 TGFBR2 TLR1 TLR6 TNFRSF1A TPM3
Entrez ID		79648	10131
HPRD ID		06174	05868
Ensembl ID		ENSG00000147316	ENSG00000126602
Uniprot IDs		Q8NEM0	A0A140VJY2 Q12931 Q53FS6
PDB IDs		2WT8 3KTF 3PA6 3SHT 3SHV 3SZM 3T1N 3U3Z 7C5D	4Z1F 4Z1G 4Z1H 4Z1I 5F3K 5F5R 5HPH 5Y3N 5Y3O 6XG6 7C04 7C05
Enriched GO Terms of Interacting Partners?
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