MCPH1 and ABCC2

Data Source:
BioGRID (two hybrid)

		MCPH1	ABCC2
Description		microcephalin 1	ATP binding cassette subfamily C member 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Microtubule Organizing Center	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Brush Border Membrane Intercellular Canaliculus Intracellular Canaliculus
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding ATP Binding Organic Anion Transmembrane Transporter Activity ABC-type Xenobiotic Transporter Activity Bilirubin Transmembrane Transporter Activity ATPase Activity Protein Domain Specific Binding ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Cerebral Cortex Development Regulation Of Kinase Activity Regulation Of Centrosome Cycle Regulation Of Inflammatory Response Bone Development Regulation Of Chromosome Condensation Protein Localization To Centrosome Mitotic Cell Cycle Arrest Neuronal Stem Cell Population Maintenance	Drug Transmembrane Transport Inflammatory Response Response To Oxidative Stress Female Pregnancy Response To Heat Negative Regulation Of Gene Expression Mercury Ion Transport Bile Acid And Bile Salt Transport Canalicular Bile Acid Transport Bilirubin Transport Prostaglandin Transport Cellular Chloride Ion Homeostasis Response To Methotrexate Response To Estradiol Response To Glucagon Cellular Response To Drug Bile Acid Signaling Pathway Xenobiotic Catabolic Process Response To Estrogen Drug Export Response To Arsenic-containing Substance Transmembrane Transport Thyroid Hormone Transport Transepithelial Transport Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Dexamethasone Stimulus Leukotriene Transport Response To Antineoplastic Agent Regulation Of Bile Acid Secretion Transport Across Blood-brain Barrier Benzylpenicillin Metabolic Process Response To 17alpha-ethynylestradiol Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Xenobiotic Transport Across Blood-brain Barrier
Pathways		Condensation of Prophase Chromosomes	Heme degradation ABC-family proteins mediated transport Defective ABCC2 causes DJS
Drugs			ATP Sulfinpyrazone
Diseases		Primary microcephaly (MCPH)	Hyperbilirubinemia; Crigler-Najjar syndrome, type I (CN1); Crigler-Najjar syndrome, type II (CN2); Gilbert Syndrome; Dubin-Johnson syndrome (DJS)
GWAS		Alcoholic chronic pancreatitis ( 28754779) Birth weight ( 31043758) Carotid intima media thickness ( 30510157) Carotid intima media thickness (mean) ( 31801372) Cytomegalovirus antibody response ( 21993531) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Epirubicin-induced leukopenia ( 21799462) Estimated glomerular filtration rate ( 31152163) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Heel bone mineral density ( 30598549) Intraocular pressure ( 29785010) Metabolite levels ( 23823483) Post bronchodilator FEV1/FVC ratio ( 26634245) Venlafaxine response in generalised anxiety disorder (remitters vs non-remitters after 24 weeks) ( 28437668)	Carboplatin disposition in epthelial ovarian cancer ( 29367611) Colorectal cancer ( 26151821 24737748) Stent thrombosis in response to clopidogrel treatment ( 32472697)
Interacting Genes		68 interacting genes: ABCC2 ACTG1 AKIP1 AKR7A2 ATM ATR B3GALT6 CCDC77 CCT5 CHEK1 COL1A1 COL27A1 COPB2 COPS3 CTSL DNAJA3 DNAJC19 EIF3F EIF4A2 EMG1 ENO1 FBLN1 FLNA GABARAPL2 HNRNPA2B1 HSPD1 KAT5 KDM1A LAMTOR5 LGALS3 MCM2 MCM5 MITD1 MRPL46 MT2A NCCRP1 NMI NR2F1 OBSL1 PHF11 PMVK POLD1 POLR2G PPA1 PPRC1 RACK1 RBM39 RSL24D1 RUVBL2 S100A16 SMARCB1 SMARCC2 SMOX SUPT6H TADA2A TAF1D THAP11 TPT1 TRAP1 TSEN54 UXT VIM WDR53 WDR61 WDR73 WDR75 WNT10B ZMIZ2	12 interacting genes: AZIN1 CANX HSPA4 MCPH1 NFKB1 PDZD3 PDZK1 RDX SHANK3 SLC9A3R1 TUBB3 UBQLN1
Entrez ID		79648	1244
HPRD ID		06174	03065
Ensembl ID		ENSG00000147316	ENSG00000023839
Uniprot IDs		Q8NEM0	Q92887
PDB IDs		2WT8 3KTF 3PA6 3SHT 3SHV 3SZM 3T1N 3U3Z 7C5D
Enriched GO Terms of Interacting Partners?
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