TRAP1 and TLR6

Data Source:
HPRD (two hybrid)

		TRAP1	TLR6
Description		TNF receptor associated protein 1	toll like receptor 6
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Membrane	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Phagocytic Vesicle Membrane Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex Receptor Complex Membrane Raft
	Molecular Function	RNA Binding Tumor Necrosis Factor Receptor Binding Protein Binding ATP Binding Protein Kinase Binding Unfolded Protein Binding	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Signaling Receptor Binding Protein Binding Toll-like Receptor 2 Binding Signaling Receptor Activity Identical Protein Binding Protein Heterodimerization Activity NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating Lipopeptide Binding
	Biological Process	Protein Folding Translational Attenuation Chaperone-mediated Protein Folding Negative Regulation Of Cellular Respiration Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide	Microglial Cell Activation Cell Activation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Gene Expression Interleukin-1 Beta Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-6 Production Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 6 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Detection Of Diacyl Bacterial Lipopeptide Defense Response To Bacterium Positive Regulation Of Macrophage Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JUN Kinase Activity Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Nitric Oxide Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Bacterial Lipopeptide Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Amyloid-beta
Pathways		Respiratory electron transport	ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR6:TLR2 Cascade MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand
Drugs
Diseases
GWAS		Asthma ( 32296059) Estimated glomerular filtration rate ( 31152163 31451708) Granulocyte count ( 27863252) Infliximab-induced mucosal healing in Crohn's disease ( 31039275) Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic sensitization ( 30013184 23817571) Allergy ( 27182965) Asthma ( 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Helicobacter pylori serologic status ( 23652523) Self-reported allergy ( 23817569)
Interacting Genes		16 interacting genes: APP ESX1 EXT1 EXT2 HGS MCPH1 PSMC4 PTGER4 RB1 SMAD4 TGFBR1 TGFBR2 TLR1 TLR6 TNFRSF1A TPM3	4 interacting genes: BTK HRAS TLR2 TRAP1
Entrez ID		10131	10333
HPRD ID		05868	05656
Ensembl ID		ENSG00000126602	ENSG00000174130
Uniprot IDs		A0A140VJY2 Q12931 Q53FS6	B2R933 Q9Y2C9
PDB IDs		4Z1F 4Z1G 4Z1H 4Z1I 5F3K 5F5R 5HPH 5Y3N 5Y3O 6XG6 7C04 7C05	4OM7
Enriched GO Terms of Interacting Partners?
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