PAK5 and INKA1

Data Source:
BioGRID (two hybrid)

		PAK5	INKA1
Description		p21 (RAC1) activated kinase 5	inka box actin regulator 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Synapse	Nucleus Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity
	Biological Process	Regulation Of Cell Growth Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Signal Transduction Learning Memory Locomotory Behavior Cell Population Proliferation Cell Migration Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Protein Serine/threonine Kinase Activity
Pathways		Activation of RAC1
Drugs		Fostamatinib
Diseases
GWAS		Atopy ( 28927820) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701)
Interacting Genes		34 interacting genes: ARHGEF19 ARMC7 ATPAF2 BAD CARD9 CATSPER1 CCDC57 CCNG1 CDC42 CRBN CSNK1D DDX6 DNPEP EMD ENKD1 EXOSC1 FHL3 GCC1 INKA1 LENG1 LNX1 LZTS2 MYO15B NTAQ1 PDLIM7 PRPF31 PSMF1 PTPN21 RAC1 RHOJ SORBS3 TSGA10 TUBGCP4 UXT	10 interacting genes: APP C1orf109 DDX6 GPANK1 KIF9 PAK4 PAK5 TRIM55 TRIM63 ZNF417
Entrez ID		57144	389119
HPRD ID		06423	14210
Ensembl ID		ENSG00000101349	ENSG00000185614
Uniprot IDs		B0AZM9 Q9P286	Q96EL1
PDB IDs		2F57	4XBR 4XBU
Enriched GO Terms of Interacting Partners?
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