PTTG1IP and SLC22A23

Data Source:
BioGRID (two hybrid)

		PTTG1IP	SLC22A23
Description		PTTG1 interacting protein	solute carrier family 22 member 23
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane Integral Component Of Membrane Extracellular Exosome	Integral Component Of Membrane
	Molecular Function	P53 Binding Molecular_function Protein Binding	Protein Binding Transmembrane Transporter Activity
	Biological Process	Protein Import Into Nucleus Positive Regulation Of Protein Ubiquitination Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Cellular Protein Catabolic Process	Ion Transport Transmembrane Transport
Pathways
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 30946743) Apolipoprotein A1 levels ( 32203549) Delirium ( 29631748) Gamma glutamyl transferase levels ( 29403010) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29403010) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 28957414)	Antipsychotic drug-induced QTc interval prolongation ( 20921969) Bone mineral density (femoral neck) in inflammatory bowel disease ( 29603369) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) ( 21221126) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fasting insulin (dietary factor interaction) ( 24204828) General cognitive ability ( 29844566) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Mean platelet volume ( 32888494 27863252) Nicotine dependence ( 28440896) Obesity-related traits ( 23251661) Primary biliary cholangitis ( 28425483) Red cell distribution width ( 32888494 27863252 28957414) Refractive error ( 32231278) Survival in rectal cancer ( 25866641)
Interacting Genes		11 interacting genes: AMIGO1 ATP6AP2 CLEC7A LDLRAD1 PTTG1 RAB4A SGCB SLC22A23 TMEM106C TMPRSS2 TNFSF14	17 interacting genes: ADAM33 ADIPOQ CBLIF CLCA4 CLN6 CNIH1 ERMP1 KRTAP1-3 KRTAP10-8 KRTAP5-9 MEOX2 NOTCH2NLA OLFM4 PSMA3 PTTG1IP UPK2 WFDC2
Entrez ID		754	63027
HPRD ID		04807	12904
Ensembl ID		ENSG00000183255	ENSG00000137266
Uniprot IDs		B4DPZ0 P53801	A1A5C7 Q9UFY2
PDB IDs
Enriched GO Terms of Interacting Partners?
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