YES1 and SKAP2

  • Data Source:
  • BioGRID (protein complementation assay)

YES1

SKAP2

Description YES proto-oncogene 1, Src family tyrosine kinase src kinase associated phosphoprotein 2
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007)
  • Chronic venous disease ( 28374850)
  • Disease free survival in colon cancer ( 31811950)
  • Erosive tooth wear (severe vs non-severe) ( 29898447)
  • Erosive tooth wear (severe vs none or mild) ( 29898447)
  • FEV1 ( 30804560)
  • Lung function (FVC) ( 30804560)
  • Lymphocyte counts ( 32888494)
  • Lymphocyte percentage of white cells ( 32888494)
  • Macular thickness ( 30535121)
  • Monocyte count ( 32888494)
  • Peak expiratory flow ( 30804560)
  • Small cell lung carcinoma ( 28604730)
  • Survival in colon cancer ( 31811950)
  • Systemic lupus erythematosus ( 28714469)
Interacting Genes 98 interacting genes: ADAM12 ADAM15 AMOTL2 AR BCAR1 BECN1 BICD2 C1orf94 CARD9 CBL CBLB CBLC CCDC33 CD2AP CD36 CD46 CDH1 CDKN1B CEP57L1 CEP83 CHMP1A CPSF6 CRKL CSF1R DDIT4L DENND2C DES DLG4 DOK1 DOK2 DTX3 DVL2 EFS EGFR EPHB2 ERBB2 ERBB3 ERBB4 FASLG FGFR1 FLACC1 FLT1 FUNDC1 FXR1 FXR2 GAB1 GAS8 GFAP GP6 IKZF3 ITGB4 JAK2 JAKMIP1 KDR KHDRBS1 KIT LASP1 LIN7C MET MST1R NEDD4 NIF3L1 NPHS1 OGT PAK2 PDCD6IP PDGFRB PECAM1 PICK1 PIK3R3 PTEN PTK2 PTPRE PXN RASA1 RPL10 SH3GLB2 SKAP2 SLC9A3R1 SOCS2 SOCS3 SOCS7 SPRR2A SSBP3 STAP2 THAP1 TNK2 TP53BP2 TRAF2 TRAF6 TRIM5 TRPV4 TSGA10IP TYRO3 ZBTB8A ZC2HC1A ZNF438 ZNF512B 20 interacting genes: APP BLK DNAJB6 FAM102A FASLG FGR FRK FYB1 FYN HCK KHDRBS1 LCK LYN NCK2 PRAM1 PTK2B SRC SRMS TGFBR1 YES1
Entrez ID 7525 8935
HPRD ID 01285 05558
Ensembl ID ENSG00000176105 ENSG00000005020
Uniprot IDs P07947 B7Z5R3 O75563
PDB IDs 2HDA 3OMH
Enriched GO Terms of Interacting Partners?
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