SKAP2 and SRMS

Data Source:
BioGRID (protein complementation assay)

		SKAP2	SRMS
Description		src kinase associated phosphoprotein 2	src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Cytoplasm Cytosol Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Protein Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation B Cell Activation Protein-containing Complex Assembly	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation Cell Differentiation Peptidyl-tyrosine Autophosphorylation Innate Immune Response
Pathways		Signal regulatory protein family interactions	PTK6 Down-Regulation
Drugs			Fostamatinib
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic venous disease ( 28374850) Disease free survival in colon cancer ( 31811950) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) FEV1 ( 30804560) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Macular thickness ( 30535121) Monocyte count ( 32888494) Peak expiratory flow ( 30804560) Small cell lung carcinoma ( 28604730) Survival in colon cancer ( 31811950) Systemic lupus erythematosus ( 28714469)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Prostate cancer ( 23535732)
Interacting Genes		20 interacting genes: APP BLK DNAJB6 FAM102A FASLG FGR FRK FYB1 FYN HCK KHDRBS1 LCK LYN NCK2 PRAM1 PTK2B SRC SRMS TGFBR1 YES1	5 interacting genes: DUXAP9 NCK2 NEDD4 NEDD4L SKAP2
Entrez ID		8935	6725
HPRD ID		05558	10250
Ensembl ID		ENSG00000005020	ENSG00000125508
Uniprot IDs		B7Z5R3 O75563	Q9H3Y6
PDB IDs		3OMH
Enriched GO Terms of Interacting Partners?
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