VWF and P4HB

Data Source:
BioGRID (pull down)

		VWF	P4HB
Description		von Willebrand factor	prolyl 4-hydroxylase subunit beta
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Weibel-Palade Body Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Cytoskeleton Focal Adhesion External Side Of Plasma Membrane Procollagen-proline 4-dioxygenase Complex Lamellipodium Protein-containing Complex Melanosome Extracellular Exosome
	Molecular Function	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Immunoglobulin Binding Identical Protein Binding Protein N-terminus Binding Chaperone Binding	RNA Binding Protein Disulfide Isomerase Activity Actin Binding Procollagen-proline 4-dioxygenase Activity Integrin Binding Protein Binding Peptide Disulfide Oxidoreductase Activity Thiol Oxidase Activity Protein Heterodimerization Activity
	Biological Process	Platelet Degranulation Cell Adhesion Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis Response To Wounding Platelet Activation Extracellular Matrix Organization Cell-substrate Adhesion	Protein Folding Protein Phosphopantetheinylation Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Chylomicron Assembly Very-low-density Lipoprotein Particle Assembly Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Cell Adhesion Positive Regulation Of Viral Entry Into Host Cell Cellular Response To Hypoxia Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Integrin cell surface interactions Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins GP1b-IX-V activation signalling MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) Signaling downstream of RAS mutants Signaling by RAF1 mutants Defective F8 cleavage by thrombin Defective F8 binding to von Willebrand factor	Collagen biosynthesis and modifying enzymes Detoxification of Reactive Oxygen Species Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Hedgehog ligand biogenesis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly Interleukin-12 signaling Interleukin-23 signaling
Drugs		Antihemophilic factor, human recombinant Egaptivon pegol Caplacizumab Simoctocog alfa Antihemophilic Factor (Recombinant), PEGylated Susoctocog alfa Efmoroctocog alfa Lonoctocog alfa Moroctocog alfa	Zinc Ribostamycin Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Hemophilia; Hemophilia A (HEMA); Hemophilia B (HEMB); von Willebrand disease (VWD)
GWAS		Blood protein levels ( 29875488) Coagulation factor levels ( 23267103) Factor VIII levels ( 20231535 30586737) Low vWF levels ( 26486471) Mean platelet volume ( 22139419 32888494 27863252) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Platelet count ( 26805783 22139419 32888494) Venous thromboembolism ( 31420334) vWF levels ( 20231535 30586737) vWF levels in ischaemic stroke and hyperhomocysteinaemia ( 28495826)
Interacting Genes		18 interacting genes: ADAMTS13 ATXN7 CACNA1A CALR COL1A1 COL1A2 COL3A1 F8 FURIN GP1BA HSPA5 ITGA2B MAP3K3 P4HB RAC1 SOCS4 TNFRSF11B ZNF512B	49 interacting genes: CD1D CHCHD2 CNNM3 COL10A1 COL1A1 COL1A2 CSNK2A2 CST2 EIF2S1 ENO1 ERO1A ERO1B ESR1 FAM71C FEZ1 FZD10 GRN HNRNPD ITGB3 KLHL42 KRTAP12-3 KRTAP13-2 KRTAP4-11 KRTAP5-9 KRTAP6-3 KRTAP9-8 LCE1B LCE2D LCE4A LCN2 LGALS9 LINC00839 LRFN4 NECTIN2 NOL4 NTM ODF1 P4HA2 P4HA3 PLCXD3 PRNP PTN SUMO2 TG TGFB1 UBQLN1 VWF YWHAG ZNF69
Entrez ID		7450	5034
HPRD ID		01906	07181
Ensembl ID		ENSG00000110799	ENSG00000185624
Uniprot IDs		P04275	A0A024R8S5 P07237
PDB IDs		1AO3 1ATZ 1AUQ 1FE8 1FNS 1IJB 1IJK 1M10 1OAK 1SQ0 1U0N 1UEX 2ADF 2MHP 2MHQ 3GXB 3HXO 3HXQ 3PPV 3PPW 3PPX 3PPY 3ZQK 4C29 4C2A 4C2B 4DMU 4NT5 5BV8 6FWN 6N29	1BJX 1MEK 1X5C 2BJX 2K18 3BJ5 3UEM 4EKZ 4EL1 4JU5 6I7S
Enriched GO Terms of Interacting Partners?
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