VWF and ADAMTS13

Data Source:
HPRD (in vitro)

		VWF	ADAMTS13
Description		von Willebrand factor	ADAM metallopeptidase with thrombospondin type 1 motif 13
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Weibel-Palade Body Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Space Endoplasmic Reticulum Lumen Cell Surface Extracellular Matrix
	Molecular Function	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Immunoglobulin Binding Identical Protein Binding Protein N-terminus Binding Chaperone Binding	Metalloendopeptidase Activity Integrin Binding Calcium Ion Binding Protein Binding Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Platelet Degranulation Cell Adhesion Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis Response To Wounding Platelet Activation Extracellular Matrix Organization Cell-substrate Adhesion	Proteolysis Cell-matrix Adhesion Integrin-mediated Signaling Pathway Glycoprotein Metabolic Process Response To Toxic Substance Response To Amine Protein Processing Platelet Activation Extracellular Matrix Organization Response To Potassium Ion Peptide Catabolic Process Cellular Response To Lipopolysaccharide Cellular Response To Interferon-gamma Cellular Response To Interleukin-4 Cellular Response To Tumor Necrosis Factor
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Integrin cell surface interactions Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins GP1b-IX-V activation signalling MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) Signaling downstream of RAS mutants Signaling by RAF1 mutants Defective F8 cleavage by thrombin Defective F8 binding to von Willebrand factor	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs		Antihemophilic factor, human recombinant Egaptivon pegol Caplacizumab Simoctocog alfa Antihemophilic Factor (Recombinant), PEGylated Susoctocog alfa Efmoroctocog alfa Lonoctocog alfa Moroctocog alfa
Diseases		Hemophilia; Hemophilia A (HEMA); Hemophilia B (HEMB); von Willebrand disease (VWD)	Thrombotic thrombocytopenic purpura; Moschcowitz disease; Schulman-Upshaw syndrome
GWAS		Blood protein levels ( 29875488) Coagulation factor levels ( 23267103) Factor VIII levels ( 20231535 30586737) Low vWF levels ( 26486471) Mean platelet volume ( 22139419 32888494 27863252) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Platelet count ( 26805783 22139419 32888494) Venous thromboembolism ( 31420334) vWF levels ( 20231535 30586737) vWF levels in ischaemic stroke and hyperhomocysteinaemia ( 28495826)	Activated partial thromboplastin time ( 22703881) ADAMTS13 activity ( 25934476) ADAMTS13 levels ( 29296746) Blood protein levels ( 29875488 28240269) Circulating fibroblast growth factor 23 levels ( 30217807) Coagulation factor levels ( 23267103) Cobalt levels ( 26025379) Gut microbiota (functional units) ( 27694959) Liver enzyme levels ( 18940312) Lymphocyte percentage of white cells ( 32888494) Malaria ( 31844061) Pancreatic cancer ( 25086665) vWF levels in ischaemic stroke and hyperhomocysteinaemia ( 28495826)
Interacting Genes		18 interacting genes: ADAMTS13 ATXN7 CACNA1A CALR COL1A1 COL1A2 COL3A1 F8 FURIN GP1BA HSPA5 ITGA2B MAP3K3 P4HB RAC1 SOCS4 TNFRSF11B ZNF512B	1 interacting genes: VWF
Entrez ID		7450	11093
HPRD ID		01906	04994
Ensembl ID		ENSG00000110799	ENSG00000160323
Uniprot IDs		P04275	Q76LX8
PDB IDs		1AO3 1ATZ 1AUQ 1FE8 1FNS 1IJB 1IJK 1M10 1OAK 1SQ0 1U0N 1UEX 2ADF 2MHP 2MHQ 3GXB 3HXO 3HXQ 3PPV 3PPW 3PPX 3PPY 3ZQK 4C29 4C2A 4C2B 4DMU 4NT5 5BV8 6FWN 6N29	3GHM 3GHN 3VN4 6QIG
Enriched GO Terms of Interacting Partners?
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