P4HB and FZD10

Data Source:
BioGRID (two hybrid)

		P4HB	FZD10
Description		prolyl 4-hydroxylase subunit beta	frizzled class receptor 10
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Cytoskeleton Focal Adhesion External Side Of Plasma Membrane Procollagen-proline 4-dioxygenase Complex Lamellipodium Protein-containing Complex Melanosome Extracellular Exosome	Nucleoplasm Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	RNA Binding Protein Disulfide Isomerase Activity Actin Binding Procollagen-proline 4-dioxygenase Activity Integrin Binding Protein Binding Peptide Disulfide Oxidoreductase Activity Thiol Oxidase Activity Protein Heterodimerization Activity	G Protein-coupled Receptor Activity Protein Binding Wnt-protein Binding Wnt-activated Receptor Activity
	Biological Process	Protein Folding Protein Phosphopantetheinylation Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Chylomicron Assembly Very-low-density Lipoprotein Particle Assembly Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Cell Adhesion Positive Regulation Of Viral Entry Into Host Cell Cellular Response To Hypoxia Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	G Protein-coupled Receptor Signaling Pathway Neuron Differentiation Regulation Of Actin Cytoskeleton Organization Negative Regulation Of GTPase Activity Non-canonical Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Via JNK Cascade Positive Regulation Of JUN Kinase Activity Positive Regulation Of GTPase Activity Canonical Wnt Signaling Pathway Cellular Response To Retinoic Acid
Pathways		Collagen biosynthesis and modifying enzymes Detoxification of Reactive Oxygen Species Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Hedgehog ligand biogenesis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly Interleukin-12 signaling Interleukin-23 signaling	Class B/2 (Secretin family receptors)
Drugs		Zinc Ribostamycin Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS			Male-pattern baldness ( 27182965)
Interacting Genes		49 interacting genes: CD1D CHCHD2 CNNM3 COL10A1 COL1A1 COL1A2 CSNK2A2 CST2 EIF2S1 ENO1 ERO1A ERO1B ESR1 FAM71C FEZ1 FZD10 GRN HNRNPD ITGB3 KLHL42 KRTAP12-3 KRTAP13-2 KRTAP4-11 KRTAP5-9 KRTAP6-3 KRTAP9-8 LCE1B LCE2D LCE4A LCN2 LGALS9 LINC00839 LRFN4 NECTIN2 NOL4 NTM ODF1 P4HA2 P4HA3 PLCXD3 PRNP PTN SUMO2 TG TGFB1 UBQLN1 VWF YWHAG ZNF69	7 interacting genes: CCNDBP1 CYSRT1 KRTAP1-1 KRTAP10-8 NBPF19 NOTCH2NLA P4HB
Entrez ID		5034	11211
HPRD ID		07181	05853
Ensembl ID		ENSG00000185624	ENSG00000111432
Uniprot IDs		A0A024R8S5 P07237	Q6NSL8 Q9ULW2
PDB IDs		1BJX 1MEK 1X5C 2BJX 2K18 3BJ5 3UEM 4EKZ 4EL1 4JU5 6I7S
Enriched GO Terms of Interacting Partners?
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