ADAMTS13 and VWF

Data Source:
HPRD (in vitro)

		ADAMTS13	VWF
Description		ADAM metallopeptidase with thrombospondin type 1 motif 13	von Willebrand factor
Image
GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Lumen Cell Surface Extracellular Matrix	Extracellular Region Extracellular Space Endoplasmic Reticulum Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Weibel-Palade Body Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Metalloendopeptidase Activity Integrin Binding Calcium Ion Binding Protein Binding Metallopeptidase Activity Zinc Ion Binding	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Immunoglobulin Binding Identical Protein Binding Protein N-terminus Binding Chaperone Binding
	Biological Process	Proteolysis Cell-matrix Adhesion Integrin-mediated Signaling Pathway Glycoprotein Metabolic Process Response To Toxic Substance Response To Amine Protein Processing Platelet Activation Extracellular Matrix Organization Response To Potassium Ion Peptide Catabolic Process Cellular Response To Lipopolysaccharide Cellular Response To Interferon-gamma Cellular Response To Interleukin-4 Cellular Response To Tumor Necrosis Factor	Platelet Degranulation Cell Adhesion Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis Response To Wounding Platelet Activation Extracellular Matrix Organization Cell-substrate Adhesion
Pathways		Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Integrin cell surface interactions Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins GP1b-IX-V activation signalling MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) Signaling downstream of RAS mutants Signaling by RAF1 mutants Defective F8 cleavage by thrombin Defective F8 binding to von Willebrand factor
Drugs			Antihemophilic factor, human recombinant Egaptivon pegol Caplacizumab Simoctocog alfa Antihemophilic Factor (Recombinant), PEGylated Susoctocog alfa Efmoroctocog alfa Lonoctocog alfa Moroctocog alfa
Diseases		Thrombotic thrombocytopenic purpura; Moschcowitz disease; Schulman-Upshaw syndrome	Hemophilia; Hemophilia A (HEMA); Hemophilia B (HEMB); von Willebrand disease (VWD)
GWAS		Activated partial thromboplastin time ( 22703881) ADAMTS13 activity ( 25934476) ADAMTS13 levels ( 29296746) Blood protein levels ( 29875488 28240269) Circulating fibroblast growth factor 23 levels ( 30217807) Coagulation factor levels ( 23267103) Cobalt levels ( 26025379) Gut microbiota (functional units) ( 27694959) Liver enzyme levels ( 18940312) Lymphocyte percentage of white cells ( 32888494) Malaria ( 31844061) Pancreatic cancer ( 25086665) vWF levels in ischaemic stroke and hyperhomocysteinaemia ( 28495826)	Blood protein levels ( 29875488) Coagulation factor levels ( 23267103) Factor VIII levels ( 20231535 30586737) Low vWF levels ( 26486471) Mean platelet volume ( 22139419 32888494 27863252) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Platelet count ( 26805783 22139419 32888494) Venous thromboembolism ( 31420334) vWF levels ( 20231535 30586737) vWF levels in ischaemic stroke and hyperhomocysteinaemia ( 28495826)
Interacting Genes		1 interacting genes: VWF	18 interacting genes: ADAMTS13 ATXN7 CACNA1A CALR COL1A1 COL1A2 COL3A1 F8 FURIN GP1BA HSPA5 ITGA2B MAP3K3 P4HB RAC1 SOCS4 TNFRSF11B ZNF512B
Entrez ID		11093	7450
HPRD ID		04994	01906
Ensembl ID		ENSG00000160323	ENSG00000110799
Uniprot IDs		Q76LX8	P04275
PDB IDs		3GHM 3GHN 3VN4 6QIG	1AO3 1ATZ 1AUQ 1FE8 1FNS 1IJB 1IJK 1M10 1OAK 1SQ0 1U0N 1UEX 2ADF 2MHP 2MHQ 3GXB 3HXO 3HXQ 3PPV 3PPW 3PPX 3PPY 3ZQK 4C29 4C2A 4C2B 4DMU 4NT5 5BV8 6FWN 6N29
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?