UBE2E2 and ASXL2

Data Source:
BioGRID (enzymatic study)

		UBE2E2	ASXL2
Description		ubiquitin conjugating enzyme E2 E2	ASXL transcriptional regulator 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleoplasm PR-DUB Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity	DNA Binding Chromatin Binding Peroxisome Proliferator Activated Receptor Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Cellular Response To DNA Damage Stimulus Protein Phosphopantetheinylation ISG15-protein Conjugation Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Transcription, DNA-templated Animal Organ Morphogenesis Positive Regulation Of Lipid Storage Protein Deubiquitination Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	UCH proteinases
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Asthma ( 32296059) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Hematocrit ( 32888494) Hemoglobin ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Metabolite levels ( 23823483) Motion sickness ( 25628336) Physiological dysregulation (Mahalanobis distance) ( 32235003) Psychosis (atypical) ( 24132900) Red blood cell count ( 32888494) RR interval (tricyclic/tetracyclic antidepressant use interaction) ( 28039329) Seasonality and depression ( 30217971) Staphylococcus aureus nasal carriage (intermittent) ( 26569114) Type 2 diabetes ( 22885922 24509480 30054458 30297969 26818947 23945395 32499647 30718926 28869590) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 27918534) Visceral adipose tissue/subcutaneous adipose tissue ratio adjusted for BMI ( 27918534) Vitiligo ( 27723757)	Decreased low contrast letter acuity in multiple sclerosis ( 31289819) Heel bone mineral density ( 30598549) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Multiple myeloma ( 26007630) Multiple myeloma and monoclonal gammopathy ( 26007630) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 32203549)
Interacting Genes		75 interacting genes: APP ARIH1 ARIH2 ARRDC3 ASXL2 BARD1 BRCA1 CBL CHFR CUEDC1 CUL3 CUL9 DAZAP2 DTX3 DTX3L DZIP3 FAM9B IPO11 ITCH MARCHF3 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L NFE2L2 OTUB1 PCGF2 PDLIM2 PGPEP1 PRAM1 PRKN RBX1 RC3H2 RING1 RLIM RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF125 RNF126 RNF14 RNF166 RNF185 RNF19A RNF2 RNF25 RNF31 RNF4 RNF5 RNF8 SRPK1 SRPK2 STUB1 TRIM2 TRIM23 TRIM27 TRIM28 TRIM3 TRIM31 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 UBA1 UBOX5 WWP2 XIAP ZNRF1	7 interacting genes: APP MBD6 PRPF40A UBC UBE2E1 UBE2E2 UBE2E3
Entrez ID		7325	55252
HPRD ID		06779	10676
Ensembl ID		ENSG00000182247	ENSG00000143970
Uniprot IDs		Q96LR5	Q76L83
PDB IDs		1Y6L 6W9A
Enriched GO Terms of Interacting Partners?
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