TMEM242 and SGPL1

Data Source:
BioGRID (two hybrid)

		TMEM242	SGPL1
Description		transmembrane protein 242	sphingosine-1-phosphate lyase 1
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding	Protein Binding Sphinganine-1-phosphate Aldolase Activity Carboxy-lyase Activity Pyridoxal Phosphate Binding
	Biological Process		Luteinization Vasculogenesis Ameboidal-type Cell Migration Kidney Development Fatty Acid Metabolic Process Ceramide Metabolic Process Spermatogenesis Androgen Metabolic Process Estrogen Metabolic Process Post-embryonic Development Fibroblast Migration Hemopoiesis Sphingolipid Biosynthetic Process Sphingolipid Catabolic Process Leydig Cell Differentiation Regulation Of Multicellular Organism Growth Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Roof Of Mouth Development Face Morphogenesis Apoptotic Signaling Pathway
Pathways			Sphingolipid de novo biosynthesis
Drugs			Pyridoxal phosphate
Diseases
GWAS		Ankle-brachial index ( 31388106) General risk tolerance (MTAG) ( 30643258) Lipoprotein (a) levels ( 26377243)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Metabolite levels ( 23823483) Microalbuminuria ( 26631737) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		36 interacting genes: AQP6 ATP6V0B BCL2L13 CNR2 CYB561 EBP ELOVL4 GGT7 GHITM GJA8 GOLT1A GPR42 GRINA HSD17B11 IL10RA JAGN1 MFSD2A MFSD6 MSMO1 MTIF3 NDUFA3 PLP1 RNF5 SGPL1 SLC10A1 SLC10A6 SLC19A3 SLC29A2 SLC30A3 SYNJ2BP TMBIM1 TMEM179B TMEM31 TMEM51 TMIE VKORC1	35 interacting genes: AQP3 AQP9 BCL2L2 BRICD5 CCL4L2 CLDN19 EFNA5 ERG28 FA2H FAM177A1 FXYD3 HMOX2 IFITM3 MARCHF5 MFSD6 MIP MMD2 PAQR5 PLP2 PLPP4 RNASE10 RTP2 SCAMP5 SLC30A3 SRPK2 STATH STING1 STX4 STX8 TMEM176A TMEM242 TMEM97 TRARG1 TSPAN4 UNC50
Entrez ID		729515	8879
HPRD ID			07224
Ensembl ID		ENSG00000215712	ENSG00000166224
Uniprot IDs		Q9NWH2	O95470
PDB IDs			4Q6R
Enriched GO Terms of Interacting Partners?
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