SGPL1 and AQP3

Data Source:
BioGRID (two hybrid)

		SGPL1	AQP3
Description		sphingosine-1-phosphate lyase 1	aquaporin 3 (Gill blood group)
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane	Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Integral Component Of Membrane Basolateral Plasma Membrane
	Molecular Function	Protein Binding Sphinganine-1-phosphate Aldolase Activity Carboxy-lyase Activity Pyridoxal Phosphate Binding	Protein Binding Urea Transmembrane Transporter Activity Water Channel Activity Glycerol Channel Activity Identical Protein Binding
	Biological Process	Luteinization Vasculogenesis Ameboidal-type Cell Migration Kidney Development Fatty Acid Metabolic Process Ceramide Metabolic Process Spermatogenesis Androgen Metabolic Process Estrogen Metabolic Process Post-embryonic Development Fibroblast Migration Hemopoiesis Sphingolipid Biosynthetic Process Sphingolipid Catabolic Process Leydig Cell Differentiation Regulation Of Multicellular Organism Growth Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Roof Of Mouth Development Face Morphogenesis Apoptotic Signaling Pathway	Positive Regulation Of Immune System Process Renal Water Homeostasis Water Transport Glycerol Transport Response To Retinoic Acid Response To Vitamin D Odontogenesis Regulation Of Keratinocyte Differentiation Response To Calcium Ion Renal Water Absorption Cellular Response To Hypoxia Urea Transmembrane Transport Cellular Response To Oxygen-glucose Deprivation
Pathways		Sphingolipid de novo biosynthesis	Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins
Drugs		Pyridoxal phosphate	Sennosides
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Metabolite levels ( 23823483) Microalbuminuria ( 26631737) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Lung adenocarcinoma ( 28604730 31326317) Neuroblastoma or malignant cutaneous melanoma ( 31605138)
Interacting Genes		35 interacting genes: AQP3 AQP9 BCL2L2 BRICD5 CCL4L2 CLDN19 EFNA5 ERG28 FA2H FAM177A1 FXYD3 HMOX2 IFITM3 MARCHF5 MFSD6 MIP MMD2 PAQR5 PLP2 PLPP4 RNASE10 RTP2 SCAMP5 SLC30A3 SRPK2 STATH STING1 STX4 STX8 TMEM176A TMEM242 TMEM97 TRARG1 TSPAN4 UNC50	28 interacting genes: C14orf180 CD79A ERG28 ERGIC3 EVI2B FAM209A GIMAP5 GPR152 GPX8 HIBADH LEUTX LMNA MFF MGST3 MRM1 MUC1 OLFM4 PLD2 PLP2 SAR1A SGPL1 SSMEM1 STX1A TMEM107 TMEM42 TMEM86A TNF VASN
Entrez ID		8879	360
HPRD ID		07224	08970
Ensembl ID		ENSG00000166224	ENSG00000165272
Uniprot IDs		O95470	A0A2R8Y2R4 Q92482
PDB IDs		4Q6R
Enriched GO Terms of Interacting Partners?
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