TUBG1 and DDX41

Data Source:
BioGRID (two hybrid)

		TUBG1	DDX41
Description		tubulin gamma 1	DEAD-box helicase 41
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GO Annotations	Cellular Component	Condensed Nuclear Chromosome Gamma-tubulin Complex Nucleus Cytoplasm Centrosome Spindle Polar Microtubule Cytosol Microtubule Recycling Endosome Mitotic Spindle Microtubule	Nucleus Spliceosomal Complex Cytosol Membrane Catalytic Step 2 Spliceosome
	Molecular Function	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Identical Protein Binding	RNA Binding RNA Helicase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Mitotic Sister Chromatid Segregation G2/M Transition Of Mitotic Cell Cycle Meiotic Spindle Organization Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule Nucleation Mitotic Spindle Organization Regulation Of G2/M Transition Of Mitotic Cell Cycle Cytoplasmic Microtubule Organization Ciliary Basal Body-plasma Membrane Docking	MRNA Splicing, Via Spliceosome Apoptotic Process Cell Population Proliferation Cell Differentiation Positive Regulation Of Type I Interferon Production
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA IRF3-mediated induction of type I IFN
Drugs		Vinblastine
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)	Coronary artery disease ( 29212778) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		28 interacting genes: APP BRCA1 CENPJ CNTN2 CUL4A DDX41 IKBKG KIF14 KRT18 KRT19 MARK4 NAPG NDE1 PCNT PIK3R1 PLK1 PXN RACGAP1 RACK1 RASSF1 RNF19A RPGR SPATC1 TUBA1B TUBA3C TUBB4B TUBGCP3 TUBGCP4	7 interacting genes: AIDA CEP70 CHAF1A KLC2 NKAPL SIAH1 TUBG1
Entrez ID		7283	51428
HPRD ID		01853	10490
Ensembl ID		ENSG00000131462	ENSG00000183258
Uniprot IDs		P23258	B3KRK2 Q9UJV9
PDB IDs		1Z5V 1Z5W 3CB2 6V5V 6V6S	2P6N 5GVR 5GVS 5H1Y
Enriched GO Terms of Interacting Partners?
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