TUBG1 and TUBA1B

Data Source:
HPRD (in vitro)

		TUBG1	TUBA1B
Description		tubulin gamma 1	tubulin alpha 1b
Image
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Gamma-tubulin Complex Nucleus Cytoplasm Centrosome Spindle Polar Microtubule Cytosol Microtubule Recycling Endosome Mitotic Spindle Microtubule	Cytoplasm Microtubule Cytoplasmic Microtubule Microtubule Cytoskeleton Membrane Raft
	Molecular Function	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Identical Protein Binding	Double-stranded RNA Binding GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Ubiquitin Protein Ligase Binding
	Biological Process	Mitotic Sister Chromatid Segregation G2/M Transition Of Mitotic Cell Cycle Meiotic Spindle Organization Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule Nucleation Mitotic Spindle Organization Regulation Of G2/M Transition Of Mitotic Cell Cycle Cytoplasmic Microtubule Organization Ciliary Basal Body-plasma Membrane Docking	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Cytoskeleton-dependent Intracellular Transport Cell Division Cellular Response To Interleukin-4
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) Recruitment of NuMA to mitotic centrosomes Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins
Drugs		Vinblastine	Epothilone D Patupilone CYT997 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)	Ambidextrousness ( 32989287) Bipolar disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Left-handedness ( 32989287)
Interacting Genes		28 interacting genes: APP BRCA1 CENPJ CNTN2 CUL4A DDX41 IKBKG KIF14 KRT18 KRT19 MARK4 NAPG NDE1 PCNT PIK3R1 PLK1 PXN RACGAP1 RACK1 RASSF1 RNF19A RPGR SPATC1 TUBA1B TUBA3C TUBB4B TUBGCP3 TUBGCP4	31 interacting genes: A2M AGTRAP CCT2 EPN2 ESR1 FYN GRM7 GZMM HDAC6 MAPT MINK1 MTCL1 MYC NFKBIA PFDN5 PIK3R1 PSEN1 PTEN PTP4A1 PTPRF PXN SIAH1 SLX1B SMAD2 SNAP91 SRPK2 SUMO2 TERT TMEM253 TOM1L1 TUBG1
Entrez ID		7283	10376
HPRD ID		01853	03960
Ensembl ID		ENSG00000131462	ENSG00000123416
Uniprot IDs		P23258	P68363
PDB IDs		1Z5V 1Z5W 3CB2 6V5V 6V6S	2E4H 5IJ0 5IJ9 5N5N 6E7B 6E7C 6I2I 6J4V 6J8O 6QUS 6QUY 6QVE 6QVJ 6S8L
Enriched GO Terms of Interacting Partners?
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