TUBG1 and CENPJ

Data Source:
HPRD (in vivo)

		TUBG1	CENPJ
Description		tubulin gamma 1	centromere protein J
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GO Annotations	Cellular Component	Condensed Nuclear Chromosome Gamma-tubulin Complex Nucleus Cytoplasm Centrosome Spindle Polar Microtubule Cytosol Microtubule Recycling Endosome Mitotic Spindle Microtubule	Nucleus Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Microtubule Plasma Membrane Gamma-tubulin Small Complex
	Molecular Function	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Identical Protein Binding	Transcription Coactivator Activity Protein Binding Tubulin Binding Protein Kinase Binding Protein Domain Specific Binding Identical Protein Binding Gamma-tubulin Binding
	Biological Process	Mitotic Sister Chromatid Segregation G2/M Transition Of Mitotic Cell Cycle Meiotic Spindle Organization Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule Nucleation Mitotic Spindle Organization Regulation Of G2/M Transition Of Mitotic Cell Cycle Cytoplasmic Microtubule Organization Ciliary Basal Body-plasma Membrane Docking	G2/M Transition Of Mitotic Cell Cycle Microtubule Nucleation Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Astral Microtubule Nucleation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Centriole Replication Microtubule Polymerization Cell Division Cilium Assembly Centriole Elongation Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Centriole Elongation Positive Regulation Of Establishment Of Protein Localization
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain AURKA Activation by TPX2
Drugs		Vinblastine
Diseases			Seckel syndrome Primary microcephaly (MCPH)
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)
Interacting Genes		28 interacting genes: APP BRCA1 CENPJ CNTN2 CUL4A DDX41 IKBKG KIF14 KRT18 KRT19 MARK4 NAPG NDE1 PCNT PIK3R1 PLK1 PXN RACGAP1 RACK1 RASSF1 RNF19A RPGR SPATC1 TUBA1B TUBA3C TUBB4B TUBGCP3 TUBGCP4	15 interacting genes: ATN1 BCCIP CIC CREBBP EPB41 FBXO7 GFI1B LAG3 LYST MTDH STAT5A STAT5B TUBG1 YWHAG YWHAZ
Entrez ID		7283	55835
HPRD ID		01853	09876
Ensembl ID		ENSG00000131462	ENSG00000151849
Uniprot IDs		P23258	A8K8P1 F6VUX8 Q9HC77
PDB IDs		1Z5V 1Z5W 3CB2 6V5V 6V6S	5EIB 5ITZ
Enriched GO Terms of Interacting Partners?
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