TTPA and DHODH

Data Source:
BioGRID (two hybrid)

		TTPA	DHODH
Description		alpha tocopherol transfer protein	dihydroorotate dehydrogenase (quinone)
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GO Annotations	Cellular Component	Late Endosome Cytosol	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol Integral Component Of Membrane Neuronal Cell Body
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Vitamin E Binding Phosphatidylinositol-3,4-bisphosphate Binding Lipid Transfer Activity Phosphatidylinositol Bisphosphate Binding	Dihydroorotate Dehydrogenase Activity Protein Binding Drug Binding FMN Binding Ubiquinone Binding
	Biological Process	Lipid Metabolic Process Response To Nutrient Response To PH Developmental Process Vitamin E Metabolic Process Vitamin Transport Intracellular PH Reduction Negative Regulation Of Cell Death Intermembrane Lipid Transfer	'de Novo' Pyrimidine Nucleobase Biosynthetic Process Female Pregnancy Lactation Pyrimidine Ribonucleotide Biosynthetic Process Response To Caffeine Response To Drug Response To Starvation Positive Regulation Of Apoptotic Process 'de Novo' UMP Biosynthetic Process Pyrimidine Nucleoside Biosynthetic Process Regulation Of Mitochondrial Fission Response To L-arginine
Pathways		Vitamin E	Pyrimidine biosynthesis
Drugs			Leflunomide Atovaquone Orotic acid Capric dimethyl amine oxide Flavin mononucleotide Brequinar Analog Brequinar Dodecyldimethylamine N-oxide 2-[4-(4-Chlorophenyl)Cyclohexylidene]-3,4-Dihydroxy-1(2h)-Naphthalenone 5-Carbamoyl-1,1':4',1''-terphenyl-3-carboxylic acid SC12267 Manitimus (2Z)-N-biphenyl-4-yl-2-cyano-3-hydroxybut-2-enamide (2Z)-2-cyano-N-(2,2'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamide (2Z)-2-cyano-N-(3'-ethoxybiphenyl-4-yl)-3-hydroxybut-2-enamide UNDECYLAMINE-N,N-DIMETHYL-N-OXIDE 2-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACID 3-{[(3-FLUORO-3'-METHOXYBIPHENYL-4-YL)AMINO]CARBONYL}THIOPHENE-2-CARBOXYLIC ACID 3-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)THIOPHENE-2-CARBOXYLIC ACID 2-({[2,3,5,6-TETRAFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENTA-1,3-DIENE-1-CARBOXYLIC ACID N-anthracen-2-yl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine 5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine (2Z)-N-biphenyl-4-yl-2-cyano-3-cyclopropyl-3-hydroxyprop-2-enamide (2Z)-N-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide 3,6,9,12,15-PENTAOXATRICOSAN-1-OL Teriflunomide
Diseases		Ataxia with isolated vitamin E deficiency (AVED); Friedreich-like ataxia
GWAS			Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Bone mineral density (hip) ( 30172743) Fibrinogen levels ( 28107422) Hand grip strength ( 29691431) Low density lipoprotein cholesterol levels ( 29403010) Morning person ( 30696823) Number of sexual partners ( 30643258) Total cholesterol levels ( 29403010)
Interacting Genes		46 interacting genes: AGTRAP APOA5 APOC2 APP ARFIP2 ARMC12 BIRC7 CISD2 CMTM4 CMTM5 COQ3 CYSRT1 DGAT2L6 DHODH FADS6 FAM114A2 FAM25A FAM25C FAM25G FGF14 FKBP7 GOLGA2 HSD17B11 JOSD2 KRTAP10-7 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 LEUTX MAL2 MRM1 NBPF19 NDUFA7 NOTCH2NLA PEX12 REEP2 RPRM SAR1A SCAMP1 SCAMP5 SDR16C5 SLC35E3 SYNGR3 THAP4 TPD52	4 interacting genes: MT2A RNF19B TMED10 TTPA
Entrez ID		7274	1723
HPRD ID		02685	00521
Ensembl ID		ENSG00000137561	ENSG00000102967
Uniprot IDs		P49638	Q02127
PDB IDs		1OIP 1OIZ 1R5L 5MUE 5MUG	1D3G 1D3H 2B0M 2BXV 2FPT 2FPV 2FPY 2FQI 2PRH 2PRL 2PRM 2WV8 3F1Q 3FJ6 3FJL 3G0U 3G0X 3KVJ 3KVK 3KVL 3KVM 3U2O 3W7R 3ZWS 3ZWT 4IGH 4JGD 4JS3 4JTS 4JTT 4JTU 4LS0 4LS1 4LS2 4OQV 4RK8 4RKA 4RLI 4RR4 4YLW 4ZL1 4ZMG 5H2Z 5H73 5HIN 5HQE 5K9C 5K9D 5MUT 5MVC 5MVD 5TCE 5ZF4 5ZF7 5ZF8 5ZF9 5ZFA 5ZFB 6CJF 6CJG 6ET4 6FMD 6GK0 6IDJ 6J3B 6J3C 6JMD 6JME 6LP6 6LP7 6LP8 6LZL 6OC0 6OC1 6QU7 6SYP 6VND 7K2U
Enriched GO Terms of Interacting Partners?
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