TTPA and JOSD2

Data Source:
BioGRID (two hybrid)

		TTPA	JOSD2
Description		alpha tocopherol transfer protein	Josephin domain containing 2
Image
GO Annotations	Cellular Component	Late Endosome Cytosol	Cytosol
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Vitamin E Binding Phosphatidylinositol-3,4-bisphosphate Binding Lipid Transfer Activity Phosphatidylinositol Bisphosphate Binding	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding
	Biological Process	Lipid Metabolic Process Response To Nutrient Response To PH Developmental Process Vitamin E Metabolic Process Vitamin Transport Intracellular PH Reduction Negative Regulation Of Cell Death Intermembrane Lipid Transfer	Protein Deubiquitination Protein Phosphopantetheinylation
Pathways		Vitamin E	Josephin domain DUBs
Drugs
Diseases		Ataxia with isolated vitamin E deficiency (AVED); Friedreich-like ataxia
GWAS
Interacting Genes		46 interacting genes: AGTRAP APOA5 APOC2 APP ARFIP2 ARMC12 BIRC7 CISD2 CMTM4 CMTM5 COQ3 CYSRT1 DGAT2L6 DHODH FADS6 FAM114A2 FAM25A FAM25C FAM25G FGF14 FKBP7 GOLGA2 HSD17B11 JOSD2 KRTAP10-7 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 LEUTX MAL2 MRM1 NBPF19 NDUFA7 NOTCH2NLA PEX12 REEP2 RPRM SAR1A SCAMP1 SCAMP5 SDR16C5 SLC35E3 SYNGR3 THAP4 TPD52	13 interacting genes: AHCYL1 CMTM5 COQ8A FKBP7 MDK PLA2G2A STUB1 SYP TRAPPC2 TRAPPC2B TTPA UBC YIF1A
Entrez ID		7274	126119
HPRD ID		02685	15297
Ensembl ID		ENSG00000137561	ENSG00000161677
Uniprot IDs		P49638	A0A024R4G2 Q7Z7N5 Q8TAC2
PDB IDs		1OIP 1OIZ 1R5L 5MUE 5MUG	6PGV
Enriched GO Terms of Interacting Partners?
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