TPM4 and PACSIN1

Data Source:
BioGRID (two hybrid)

		TPM4	PACSIN1
Description		tropomyosin 4	protein kinase C and casein kinase substrate in neurons 1
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Focal Adhesion Membrane Extracellular Exosome	Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane COPI-coated Vesicle Cytoplasmic Vesicle Membrane Ruffle Membrane Axon Terminus Synapse Perinuclear Region Of Cytoplasm Photoreceptor Ribbon Synapse Presynaptic Endocytic Zone
	Molecular Function	Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding	Protein Binding Phospholipid Binding Identical Protein Binding
	Biological Process	Osteoblast Differentiation Muscle Contraction Actin Filament Organization Muscle Filament Sliding	Cytoskeleton Organization Actin Filament Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Synaptic Vesicle Endocytosis Neuron Projection Morphogenesis Protein Localization To Membrane Protein Localization To Plasma Membrane Plasma Membrane Tubulation Positive Regulation Of Dendrite Development
Pathways		Striated Muscle Contraction Smooth Muscle Contraction	Clathrin-mediated endocytosis
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Mean platelet volume ( 31080455 22139419 32888494 22423221 27863252) Platelet count ( 26805783 22139419 32888494 22423221 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Electrocardiographic traits ( 32602732) Free thyroxine concentration ( 30367059) High density lipoprotein cholesterol levels ( 30498476) Inflammatory bowel disease ( 27569725) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		11 interacting genes: JRK LNX1 NOD2 PACSIN1 PICK1 SMURF1 SNAPIN TCERG1 TPM1 TPM3 TRIP6	25 interacting genes: ANKRD24 ARHGAP17 DNM1 EHBP1 FTH1 GAS7 HTT ITCH JADE2 KAT7 KHDRBS1 MAPT MT-ATP8 PACSIN2 PACSIN3 PLEKHF2 POT1 RTKN2 SOS1 SPTBN1 SYNJ1 TPM4 TRPV4 WASF2 WASL
Entrez ID		7171	29993
HPRD ID		11734	05936
Ensembl ID		ENSG00000167460	ENSG00000124507
Uniprot IDs		A0A5F9UN72 K7ENT6 P67936 V9HW56	Q5TZC3 Q9BY11
PDB IDs			3HAH 3HAI 3Q84 3QNI
Enriched GO Terms of Interacting Partners?
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