TPM4 and TCERG1

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		TPM4	TCERG1
Description		tropomyosin 4	transcription elongation regulator 1
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Focal Adhesion Membrane Extracellular Exosome	Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding	RNA Polymerase II Repressing Transcription Factor Binding Transcription Elongation Regulator Activity Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Protein Binding Identical Protein Binding Ubiquitin-like Protein Conjugating Enzyme Binding RNA Polymerase Binding
	Biological Process	Osteoblast Differentiation Muscle Contraction Actin Filament Organization Muscle Filament Sliding	Negative Regulation Of Transcription By RNA Polymerase II MRNA Processing RNA Splicing Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Striated Muscle Contraction Smooth Muscle Contraction
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Mean platelet volume ( 31080455 22139419 32888494 22423221 27863252) Platelet count ( 26805783 22139419 32888494 22423221 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252)	Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		11 interacting genes: JRK LNX1 NOD2 PACSIN1 PICK1 SMURF1 SNAPIN TCERG1 TPM1 TPM3 TRIP6	54 interacting genes: ABI1 AURKA BARD1 CHAF1A CHD3 CPSF6 CYFIP1 CYFIP2 DIAPH1 DIAPH2 DNAJB9 ESR1 EVL FANCA FANCC FMNL1 GRB2 HNRNPH1 HNRNPK HNRNPM HNRNPU HSPA1A HSPA5 HSPA8 HTT JUNB LUC7L NONO NPM1 NUDT21 PCBP1 PIAS4 POLR2A PSPC1 SETDB1 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SRSF1 SUMO2 TPM4 U2AF2 UBE2I WAS WASF2 WBP4 WIPF2 WWOX
Entrez ID		7171	10915
HPRD ID		11734	10393
Ensembl ID		ENSG00000167460	ENSG00000113649
Uniprot IDs		A0A5F9UN72 K7ENT6 P67936 V9HW56	O14776
PDB IDs			2DK7 2DOD 2DOE 2DOF 2E71 2KIQ 2KIS 2MW9 2MWA 2MWB 2MWD 2MWE 2MWF 2N4R 2N4S 2N4T 2N4U 2N4V 2N4W 2NNT 3HFH 3Q1I 4FQG
Enriched GO Terms of Interacting Partners?
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