C1S and C1QA

Data Source:
HPRD (in vitro)

		C1S	C1QA
Description		complement C1s	complement C1q A chain
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Blood Microparticle	Extracellular Region Collagen Trimer Complement Component C1 Complex Synapse Collagen-containing Extracellular Matrix Postsynapse
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Identical Protein Binding	Amyloid-beta Binding Protein Binding
	Biological Process	Proteolysis Complement Activation Complement Activation, Classical Pathway Regulation Of Complement Activation Innate Immune Response	Microglial Cell Activation Complement Activation Complement Activation, Classical Pathway Cell-cell Signaling Aging Response To Iron Ion Viral Process Neuron Remodeling Regulation Of Complement Activation Innate Immune Response Astrocyte Activation Synapse Organization Synapse Pruning Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning Positive Regulation Of Neuron Death
Pathways		Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade	Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs		Zinc 2-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Ethanesulfonic Acid Human C1-esterase inhibitor Copper Conestat alfa Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Cetuximab Etanercept Palivizumab Daclizumab Bevacizumab
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency	Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Activated partial thromboplastin time ( 29403010) Blood protein levels ( 29875488 28240269) Coronary artery disease ( 29212778 33020668) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Lung cancer in never smokers ( 28604730) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell fatty acid levels ( 25500335) Red cell distribution width ( 32888494 27863252) Refractive error ( 32231278)	Inflammatory biomarkers (multivariate analysis) ( 33110245)
Interacting Genes		5 interacting genes: C1QA C1R REEP4 SERPING1 VKORC1	28 interacting genes: APCS BAG6 C1QB C1QBP C1QC C1R C1S CD93 COL2A1 CR1 CRP CSPG4 DCN FN1 GNPNAT1 HIPK3 HRG HSPB2 NLGN3 PIAS2 PPP1CA PPP1CC PTX3 SGTA SGTB SLC25A47 UBQLN1 UBQLN2
Entrez ID		716	712
HPRD ID		00397	00393
Ensembl ID		ENSG00000182326	ENSG00000173372
Uniprot IDs		F8WCZ6 P09871	A0A024RAG6 P02745
PDB IDs		1ELV 1NZI 4J1Y 4LMF 4LOR 4LOS 4LOT 6F1C 6F1H	1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ 6Z6V
Enriched GO Terms of Interacting Partners?
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