TNFRSF1A and TRAF3

Data Source:
BioGRID (pull down)

		TNFRSF1A	TRAF3
Description		TNF receptor superfamily member 1A	TNF receptor associated factor 3
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GO Annotations	Cellular Component	Golgi Membrane Tumor Necrosis Factor Receptor Superfamily Complex Extracellular Region Extracellular Space Mitochondrion Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Receptor Complex Membrane Raft	Mitochondrion Endosome Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Plasma Membrane Signaling Receptor Complex
	Molecular Function	Tumor Necrosis Factor-activated Receptor Activity Protein Binding Tumor Necrosis Factor Binding	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding
	Biological Process	Aortic Valve Development Pulmonary Valve Development Negative Regulation Of Extracellular Matrix Constituent Secretion Prostaglandin Metabolic Process Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Viral Process Cytokine-mediated Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Cellular Response To Mechanical Stimulus Death-inducing Signaling Complex Assembly Protein Localization To Plasma Membrane Positive Regulation Of Apoptotic Process Involved In Morphogenesis Regulation Of Establishment Of Endothelial Barrier Positive Regulation Of Ceramide Biosynthetic Process	Regulation Of Cytokine Production Toll-like Receptor Signaling Pathway Apoptotic Process Signal Transduction Toll Signaling Pathway Protein Deubiquitination Regulation Of Proteolysis Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Interferon-beta Production Tumor Necrosis Factor-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of JNK Cascade Regulation Of Defense Response To Virus Protein K63-linked Ubiquitination
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR1-mediated ceramide production TNFs bind their physiological receptors Interleukin-10 signaling TNF signaling	TRAF3 deficiency - HSE TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ovarian tumor domain proteases TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs		6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2',3':4,5]Pyrrolo[1,2-C]Imidazol-7-One Tasonermin
Diseases		Tumor necrosis factor receptor-associated periodic syndrome (TRAPS); Familial periodic fever
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) ( 23648065) Alopecia areata ( 25608926) Ankylosing spondylitis ( 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Colorectal cancer ( 24836286) Crohn's disease ( 26192919) Eosinophil counts ( 32888494) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494 27863252) Multiple sclerosis ( 31604244 24076602 19525953 21833088 27386562) Neutrophil percentage of white cells ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Primary biliary cholangitis ( 28425483 21399635 26394269) Primary biliary cirrhosis ( 22961000) White blood cell count ( 32888494)	Adult body size ( 32376654) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Apolipoprotein A1 levels ( 32203549) Asthma ( 32296059) Asthma (childhood onset) ( 30929738) Body mass index ( 25673413 29273807) Body size at age 10 ( 32376654) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) Eczema ( 31361310) Gallstone disease ( 30692554) HDL cholesterol levels ( 32203549) Immunoglobulin measurement (zinc sulfate turbidity test) ( 29403010) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Red blood cell count ( 32888494) Serum total protein level ( 29403010) Systemic lupus erythematosus ( 33536424 28714469) Type 2 diabetes ( 32499647)
Interacting Genes		67 interacting genes: ADAM17 AKT1 ATF6 BAG4 BCL10 CASP10 CASP7 CCND2 CDK6 CDKN2B CHUK CLIP3 CSNK1A1L DAPK1 DAXX EGFR ERAP1 ERN1 FANCD2 GRB2 GYS2 HRG HSP90AA1 HSPA8 IKBKB IKBKG JAK1 JAK2 LTA LTB MADD MAGEH1 MAPK1 MOAP1 MYOC NSMAF PIP4K2B PRDX3 PRKCD PSMD2 PTK2 PTPN11 PTPN6 RACK1 RASSF1 RIPK1 RIPK2 RIPK3 SGTA SRC STAMBP STAT1 STK11 SUMO1 SYK TNF TNFRSF25 TNFSF13 TRADD TRAF1 TRAF2 TRAF3 TRAP1 TRPC4AP UBE2I UBQLN1 UCHL1	83 interacting genes: ABCC1 ALPL APOBEC3C ASCC1 AZI2 BEX3 BIRC3 BIVM C10orf62 CASP3 CCDC13 CCDC184 CD27 CD40 CDC37 CELF2 CSNK1E DAXX EDA2R EDAR EWSR1 FAS GMEB2 GRIN1 GRIN2D HEMGN HNRNPC HSPB11 IL15 IP6K3 IRF1 LNX1 LTBR MAP2K1 MAP3K14 MAP3K7 NTAQ1 NUP62 OTUD5 PDLIM7 PDZD4 PIAS2 POM121 PSMB8 RAD23A RIPK1 RIPPLY1 RNF216 RNF4 RRAS2 SAR1A SNAP29 SRC STK38 TANK TBK1 TDP2 TICAM1 TNFRSF11A TNFRSF12A TNFRSF13C TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF8 TNFRSF9 TRADD TRAF2 TRAF3IP1 TRAF3IP2 TRAF3IP3 TRAF5 TRIM37 UBE2I USP7 ZBP1 ZBTB49 ZMYND11 ZSCAN4
Entrez ID		7132	7187
HPRD ID		01861	03539
Ensembl ID		ENSG00000067182	ENSG00000131323
Uniprot IDs		J9PH39 P19438	A6NHG8 Q13114
PDB IDs		1EXT 1FT4 1ICH 1NCF 1TNR 7K7A	1FLK 1FLL 1KZZ 1L0A 1RF3 1ZMS 2ECY 2GKW
Enriched GO Terms of Interacting Partners?
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