TRAF3 and PIAS2

Data Source:
BioGRID (two hybrid)

		TRAF3	PIAS2
Description		TNF receptor associated factor 3	protein inhibitor of activated STAT 2
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GO Annotations	Cellular Component	Mitochondrion Endosome Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Plasma Membrane Signaling Receptor Complex	Nucleus Nucleoplasm PML Body Nuclear Speck
	Molecular Function	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding	RNA Polymerase II Transcription Factor Binding DNA Binding Transcription Coregulator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding SUMO Ligase Activity
	Biological Process	Regulation Of Cytokine Production Toll-like Receptor Signaling Pathway Apoptotic Process Signal Transduction Toll Signaling Pathway Protein Deubiquitination Regulation Of Proteolysis Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Interferon-beta Production Tumor Necrosis Factor-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of JNK Cascade Regulation Of Defense Response To Virus Protein K63-linked Ubiquitination	Regulation Of Transcription By RNA Polymerase II Protein Sumoylation Negative Regulation Of Androgen Receptor Signaling Pathway
Pathways		TRAF3 deficiency - HSE TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ovarian tumor domain proteases TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Adult body size ( 32376654) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Apolipoprotein A1 levels ( 32203549) Asthma ( 32296059) Asthma (childhood onset) ( 30929738) Body mass index ( 25673413 29273807) Body size at age 10 ( 32376654) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) Eczema ( 31361310) Gallstone disease ( 30692554) HDL cholesterol levels ( 32203549) Immunoglobulin measurement (zinc sulfate turbidity test) ( 29403010) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Red blood cell count ( 32888494) Serum total protein level ( 29403010) Systemic lupus erythematosus ( 33536424 28714469) Type 2 diabetes ( 32499647)	Fruit consumption ( 32066663)
Interacting Genes		83 interacting genes: ABCC1 ALPL APOBEC3C ASCC1 AZI2 BEX3 BIRC3 BIVM C10orf62 CASP3 CCDC13 CCDC184 CD27 CD40 CDC37 CELF2 CSNK1E DAXX EDA2R EDAR EWSR1 FAS GMEB2 GRIN1 GRIN2D HEMGN HNRNPC HSPB11 IL15 IP6K3 IRF1 LNX1 LTBR MAP2K1 MAP3K14 MAP3K7 NTAQ1 NUP62 OTUD5 PDLIM7 PDZD4 PIAS2 POM121 PSMB8 RAD23A RIPK1 RIPPLY1 RNF216 RNF4 RRAS2 SAR1A SNAP29 SRC STK38 TANK TBK1 TDP2 TICAM1 TNFRSF11A TNFRSF12A TNFRSF13C TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF8 TNFRSF9 TRADD TRAF2 TRAF3IP1 TRAF3IP2 TRAF3IP3 TRAF5 TRIM37 UBE2I USP7 ZBP1 ZBTB49 ZMYND11 ZSCAN4	125 interacting genes: ACY3 ADA AKT1 AR ATF2 C1QA C5orf24 CBS CBSL CCHCR1 CCNDBP1 CDCA8 CGGBP1 CHMP4B CLDN2 CREB1 CREBBP CTBP1 DDX39B DES DEUP1 DMC1 DNMT3A EDC3 ELK1 ESR1 ESR2 EXOSC8 FAM118B FKBP6 FLI1 GFAP GLUL GOLGA2 GRHL2 GRM8 GTF2I GTF2IRD1 HDAC3 HMBOX1 HMG20A HMG20B HMGXB4 HNRNPCL1 HNRNPUL1 HOMER1 HOOK1 HUWE1 IKZF1 IMPDH1 JUN KIFC3 LCE1E LCE2C LMNA LMNB1 MAPK8 MAPKAPK2 MBD1 MITF MLX MSX2 MX1 MX2 NAV2 NME7 NR3C1 PAICS PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 PRKRA PRPH RFX2 RUFY1 RUNX1T1 SEC23A SIAH1 SIAH2 SMAD3 SMAD4 SNAI2 SNIP1 SOX5 SPATC1L SPINDOC SREBF2 STAT4 SUMO1 SUMO1P1 SUMO2 SUMO3 SYN3 TH TICAM2 TP53 TRAF2 TRAF3 TRAF5 TRIM23 TRIM27 TRIM50 TRIM55 TRIM63 TSR2 TXLNA UBASH3B UBE2I UBE2L3 UBQLN1 ZBED1 ZBTB16 ZBTB8A ZC3H10 ZFP42 ZNF319 ZNF451 ZNRD2
Entrez ID		7187	9063
HPRD ID		03539	06944
Ensembl ID		ENSG00000131323	ENSG00000078043
Uniprot IDs		A6NHG8 Q13114	A0A024RC49 O75928 Q2TA77
PDB IDs		1FLK 1FLL 1KZZ 1L0A 1RF3 1ZMS 2ECY 2GKW	2ASQ 4FO9
Enriched GO Terms of Interacting Partners?
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