TNFRSF1A and ERAP1

Data Source:
HPRD (in vivo)

		TNFRSF1A	ERAP1
Description		TNF receptor superfamily member 1A	endoplasmic reticulum aminopeptidase 1
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GO Annotations	Cellular Component	Golgi Membrane Tumor Necrosis Factor Receptor Superfamily Complex Extracellular Region Extracellular Space Mitochondrion Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Receptor Complex Membrane Raft	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Tumor Necrosis Factor-activated Receptor Activity Protein Binding Tumor Necrosis Factor Binding	Aminopeptidase Activity Interleukin-6 Receptor Binding Interleukin-1, Type II Receptor Binding Protein Binding Metalloexopeptidase Activity Zinc Ion Binding Peptide Binding Metalloaminopeptidase Activity
	Biological Process	Aortic Valve Development Pulmonary Valve Development Negative Regulation Of Extracellular Matrix Constituent Secretion Prostaglandin Metabolic Process Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Viral Process Cytokine-mediated Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Cellular Response To Mechanical Stimulus Death-inducing Signaling Complex Assembly Protein Localization To Plasma Membrane Positive Regulation Of Apoptotic Process Involved In Morphogenesis Regulation Of Establishment Of Endothelial Barrier Positive Regulation Of Ceramide Biosynthetic Process	Angiogenesis Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Proteolysis Membrane Protein Ectodomain Proteolysis Signal Transduction Regulation Of Blood Pressure Response To Bacterium Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Peptide Catabolic Process Regulation Of Innate Immune Response Fat Cell Differentiation
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR1-mediated ceramide production TNFs bind their physiological receptors Interleukin-10 signaling TNF signaling	Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs		6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2',3':4,5]Pyrrolo[1,2-C]Imidazol-7-One Tasonermin
Diseases		Tumor necrosis factor receptor-associated periodic syndrome (TRAPS); Familial periodic fever
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) ( 23648065) Alopecia areata ( 25608926) Ankylosing spondylitis ( 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Colorectal cancer ( 24836286) Crohn's disease ( 26192919) Eosinophil counts ( 32888494) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494 27863252) Multiple sclerosis ( 31604244 24076602 19525953 21833088 27386562) Neutrophil percentage of white cells ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Primary biliary cholangitis ( 28425483 21399635 26394269) Primary biliary cirrhosis ( 22961000) White blood cell count ( 32888494)	Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Acute anterior uveitis in ankylosing spondylitis ( 32492107 25200001) Alcohol dependence ( 19581569) Ankylosing spondylitis ( 23749187 21743469 20062062 30946743) Behcet's disease ( 23291587) Birdshot chorioretinopathy ( 24957906) Blood protein levels ( 30072576 29875488 28240269) Body mass index ( 26426971 29273807) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Colorectal cancer ( 25990418) Emotional lability in attention deficit hyperactivity disorder ( 31085060) Hodgkin's lymphoma ( 22286212) Inflammatory bowel disease ( 23128233) Inflammatory skin disease ( 25574825) Medication use (calcium channel blockers) ( 31015401) Psoriasis ( 25854761 20953190 25574825 23143594) Psoriasis vulgaris ( 26626624) Systolic blood pressure ( 30578418) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		67 interacting genes: ADAM17 AKT1 ATF6 BAG4 BCL10 CASP10 CASP7 CCND2 CDK6 CDKN2B CHUK CLIP3 CSNK1A1L DAPK1 DAXX EGFR ERAP1 ERN1 FANCD2 GRB2 GYS2 HRG HSP90AA1 HSPA8 IKBKB IKBKG JAK1 JAK2 LTA LTB MADD MAGEH1 MAPK1 MOAP1 MYOC NSMAF PIP4K2B PRDX3 PRKCD PSMD2 PTK2 PTPN11 PTPN6 RACK1 RASSF1 RIPK1 RIPK2 RIPK3 SGTA SRC STAMBP STAT1 STK11 SUMO1 SYK TNF TNFRSF25 TNFSF13 TRADD TRAF1 TRAF2 TRAF3 TRAP1 TRPC4AP UBE2I UBQLN1 UCHL1	3 interacting genes: H3-4 IL6R TNFRSF1A
Entrez ID		7132	51752
HPRD ID		01861	06015
Ensembl ID		ENSG00000067182	ENSG00000164307
Uniprot IDs		J9PH39 P19438	Q9NZ08
PDB IDs		1EXT 1FT4 1ICH 1NCF 1TNR 7K7A	2YD0 3MDJ 3QNF 3RJO 5J5E 6M8P 6MGQ 6Q4R 6RQX 6RYF 6T6R
Enriched GO Terms of Interacting Partners?
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