TLR4 and MAPK8IP3

  • Data Source:
  • HPRD (in vivo)

TLR4

MAPK8IP3

Description toll like receptor 4 mitogen-activated protein kinase 8 interacting protein 3
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Adult body size ( 32376654)
  • Blood protein levels ( 29875488 28240269)
  • BMI (adjusted for smoking behaviour) ( 28443625)
  • BMI in non-smokers ( 28443625)
  • Body mass index ( 25673413 28448500)
  • Body mass index (joint analysis main effects and physical activity interaction) ( 28448500)
  • Body mass index (joint analysis main effects and smoking interaction) ( 28443625)
  • Body mass index in physically active individuals ( 28448500)
  • Body size at age 10 ( 32376654)
  • Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007)
  • Cognitive decline rate in late mild cognitive impairment ( 26252872)
  • Experiencing mood swings ( 29500382)
  • Feeling fed-up ( 29500382)
  • Feeling guilty ( 29500382)
  • Impulsivity (motor) ( 30718321)
  • Irritable mood ( 29500382)
  • Metabolite levels ( 23823483)
  • Neurociticism ( 29500382)
  • Neuroticism ( 29255261)
  • Obesity-related traits ( 23251661)
  • Osteoarthritis biomarkers ( 25057126)
  • Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311)
  • Prostate-specific antigen levels ( 28139693)
  • Voxel-wise structural brain imaging measurements in Alzheimer’s disease ( 30584014)
Interacting Genes 25 interacting genes: BCL10 BTK CD14 CNPY4 DEFB4A HMGB1 HSP90B1 IRAK1 IRAK2 LY96 MAPK8IP3 MYD88 NOX4 RIPK2 RNF216 SERTAD1 SIGIRR SMAD3 SYK TICAM2 TIRAP TLR1 TLR5 TOLLIP UBQLN1 26 interacting genes: ARL4D CASP3 KLC1 KLC2 LDLRAP1 MAP2K1 MAP2K4 MAP2K7 MAP3K11 MAP3K5 MAPK10 MAPK8 MAPK8IP1 MAPK8IP2 MAPK9 PTK2 RAD51 RAD51D RAF1 RIC8A SRC SULT4A1 TLR2 TLR4 TLR9 ZNF575
Entrez ID 7099 23162
HPRD ID 04325 12014
Ensembl ID ENSG00000136869 ENSG00000138834
Uniprot IDs O00206 A0A087WYG2 B7ZMF3 E9PFH7 Q9UPT6
PDB IDs 2Z62 2Z63 2Z65 2Z66 3FXI 3UL7 3UL8 3UL9 3ULA 4G8A 5NAM 5NAO 4PXJ
Enriched GO Terms of Interacting Partners?
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