TLR4 and TIRAP

  • Data Source:
  • HPRD (in vivo)

TLR4

TIRAP

Description toll like receptor 4 TIR domain containing adaptor protein
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Adult body size ( 32376654)
  • Blood protein levels ( 29875488 28240269)
  • BMI (adjusted for smoking behaviour) ( 28443625)
  • BMI in non-smokers ( 28443625)
  • Body mass index ( 25673413 28448500)
  • Body mass index (joint analysis main effects and physical activity interaction) ( 28448500)
  • Body mass index (joint analysis main effects and smoking interaction) ( 28443625)
  • Body mass index in physically active individuals ( 28448500)
  • Body size at age 10 ( 32376654)
  • Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007)
  • Cognitive decline rate in late mild cognitive impairment ( 26252872)
  • Experiencing mood swings ( 29500382)
  • Feeling fed-up ( 29500382)
  • Feeling guilty ( 29500382)
  • Impulsivity (motor) ( 30718321)
  • Irritable mood ( 29500382)
  • Metabolite levels ( 23823483)
  • Neurociticism ( 29500382)
  • Neuroticism ( 29255261)
  • Obesity-related traits ( 23251661)
  • Osteoarthritis biomarkers ( 25057126)
  • Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311)
  • Prostate-specific antigen levels ( 28139693)
  • Voxel-wise structural brain imaging measurements in Alzheimer’s disease ( 30584014)
Interacting Genes 25 interacting genes: BCL10 BTK CD14 CNPY4 DEFB4A HMGB1 HSP90B1 IRAK1 IRAK2 LY96 MAPK8IP3 MYD88 NOX4 RIPK2 RNF216 SERTAD1 SIGIRR SMAD3 SYK TICAM2 TIRAP TLR1 TLR5 TOLLIP UBQLN1 26 interacting genes: APP ARAF BTK CASP1 CCDC47 CD247 DNAJC3 EIF2AK2 IL1RL1 IRAK1 IRAK2 IRAK4 LRRK1 LTN1 MPP3 MYD88 PCNA PRKRA SAMHD1 SOCS1 TICAM1 TICAM2 TLR2 TLR4 TRAF6 TRAM1
Entrez ID 7099 114609
HPRD ID 04325 05878
Ensembl ID ENSG00000136869 ENSG00000150455
Uniprot IDs O00206 A0A024R3M4 P58753
PDB IDs 2Z62 2Z63 2Z65 2Z66 3FXI 3UL7 3UL8 3UL9 3ULA 4G8A 5NAM 5NAO 2NDH 2Y92 3UB2 3UB3 3UB4 4FZ5 4LQD 5T7Q 5UZB
Enriched GO Terms of Interacting Partners?
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