TIRAP and TICAM2

Data Source:
HPRD (in vitro)

		TIRAP	TICAM2
Description		TIR domain containing adaptor protein	toll like receptor adaptor molecule 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Endocytic Vesicle Ruffle Membrane	Phagocytic Cup Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Plasma Membrane Endosome Membrane COPII-coated ER To Golgi Transport Vesicle Secretory Granule Membrane Early Endosome Membrane Late Endosome Membrane Cell Projection
	Molecular Function	Protein Kinase C Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein-macromolecule Adaptor Activity Toll-like Receptor 4 Binding Toll-like Receptor 2 Binding Identical Protein Binding	Protein Binding
	Biological Process	MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Cell Surface Receptor Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Myeloid Cell Differentiation Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein-containing Complex Assembly Response To Lipopolysaccharide Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-15 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of JNK Cascade Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of ERK1 And ERK2 Cascade 3'-UTR-mediated MRNA Stabilization Cellular Response To Bacterial Lipopeptide Cellular Response To Lipoteichoic Acid Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	MyD88-independent Toll-like Receptor Signaling Pathway Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Phagocytosis Inflammatory Response Golgi Organization I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway TRAM-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Neutrophil Degranulation Innate Immune Response Necroptotic Process Cellular Response To Lipopolysaccharide Apoptotic Signaling Pathway Positive Regulation Of Interleukin-18-mediated Signaling Pathway
Pathways		ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4)	Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade MyD88-independent TLR4 cascade TRIF-mediated programmed cell death Neutrophil degranulation Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Eosinophil percentage of granulocytes ( 27863252) Neutrophil percentage of granulocytes ( 27863252)	Allergic disease (asthma, hay fever or eczema) ( 29679657) Response to antidepressants (symptom improvement) ( 29160301)
Interacting Genes		26 interacting genes: APP ARAF BTK CASP1 CCDC47 CD247 DNAJC3 EIF2AK2 IL1RL1 IRAK1 IRAK2 IRAK4 LRRK1 LTN1 MPP3 MYD88 PCNA PRKRA SAMHD1 SOCS1 TICAM1 TICAM2 TLR2 TLR4 TRAF6 TRAM1	19 interacting genes: FTH1 IL1R1 IL1RAP IRAK1 IRAK2 IRAK3 IRAK4 IRF3 IRF7 MEOX2 NTAQ1 OPN1LW PIAS2 SARM1 TICAM1 TIRAP TLR3 TLR4 TRAF6
Entrez ID		114609	353376
HPRD ID		05878	16313
Ensembl ID		ENSG00000150455	ENSG00000243414
Uniprot IDs		A0A024R3M4 P58753	Q86XR7
PDB IDs		2NDH 2Y92 3UB2 3UB3 3UB4 4FZ5 4LQD 5T7Q 5UZB	2M1W
Enriched GO Terms of Interacting Partners?
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