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TLR2 and TRIP6
Data Source:
HPRD
(in vivo)
TLR2
TRIP6
Description
toll like receptor 2
thyroid hormone receptor interactor 6
Image
GO Annotations
Cellular Component
Cytoplasm
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Secretory Granule Membrane
Phagocytic Vesicle Membrane
Intrinsic Component Of Plasma Membrane
Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex
Cell Projection
Cell Body
Membrane Raft
Stress Fiber
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Focal Adhesion
Molecular Function
Lipopolysaccharide Binding
Amyloid-beta Binding
Lipopolysaccharide Immune Receptor Activity
Transmembrane Signaling Receptor Activity
Protein Binding
Toll-like Receptor Binding
Signaling Receptor Activity
Pattern Recognition Receptor Activity
Triacyl Lipopeptide Binding
Identical Protein Binding
Peptidoglycan Binding
Protein-containing Complex Binding
NAD(P)+ Nucleosidase Activity
NAD+ Nucleotidase, Cyclic ADP-ribose Generating
RNA Binding
Interleukin-1 Receptor Binding
Protein Binding
Kinase Binding
Metal Ion Binding
Thyroid Hormone Receptor Binding
Biological Process
Response To Hypoxia
Microglial Cell Activation
Cell Activation
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Leukotriene Metabolic Process
Apoptotic Process
Inflammatory Response
Immune Response
Signal Transduction
I-kappaB Phosphorylation
Learning
Negative Regulation Of Cell Population Proliferation
Response To Toxic Substance
Positive Regulation Of Gene Expression
Microglia Development
Positive Regulation Of Wnt Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Central Nervous System Myelin Formation
Response To Progesterone
Interleukin-10 Production
Positive Regulation Of Chemokine Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-18 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Response To Insulin
Positive Regulation Of Toll-like Receptor Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Detection Of Triacyl Bacterial Lipopeptide
Detection Of Diacyl Bacterial Lipopeptide
Neutrophil Degranulation
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Nitric Oxide Metabolic Process
Positive Regulation Of Oligodendrocyte Differentiation
Positive Regulation Of Inflammatory Response
Negative Regulation Of Phagocytosis
Defense Response To Gram-positive Bacterium
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Negative Regulation Of Synapse Assembly
Response To Fatty Acid
Cellular Response To Bacterial Lipopeptide
Cellular Response To Lipoteichoic Acid
Cellular Response To Interferon-gamma
Cellular Response To Diacyl Bacterial Lipopeptide
Cellular Response To Triacyl Bacterial Lipopeptide
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus
Positive Regulation Of Matrix Metallopeptidase Secretion
Signal Transduction
Positive Regulation Of Cell Migration
Chordate Embryonic Development
Focal Adhesion Assembly
Positive Regulation Of NIK/NF-kappaB Signaling
Pathways
ER-Phagosome pathway
Beta defensins
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Toll Like Receptor TLR1:TLR2 Cascade
Toll Like Receptor TLR6:TLR2 Cascade
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Regulation of TLR by endogenous ligand
Neutrophil degranulation
Modulation by Mtb of host immune system
Drugs
Lyme disease vaccine (recombinant OspA)
Adapalene
S-(Dimethylarsenic)Cysteine
Golotimod
Tuberculin purified protein derivative
Diseases
GWAS
Body fat mass (
28552196
)
Bipolar disorder (
31043756
)
Heart rate increase in response to exercise (
29497042
)
Heart rate response to recovery post exercise (10 sec) (
29497042
)
Heart rate response to recovery post exercise (20 sec) (
29497042
)
Heart rate response to recovery post exercise (30 sec) (
29497042
)
Heart rate response to recovery post exercise (40 sec) (
29497042
)
Heart rate response to recovery post exercise (50 sec) (
29497042
)
Nonunion in individuals with fractures (
30680360
)
Plasminogen activator inhibitor type 1 levels (PAI-1) (
22990020
)
Interacting Genes
29 interacting genes:
AKT1
ANP32B
CD14
EGFR
FBP1
HEMGN
HMGB1
HRAS
HSP90B1
IRAK1
LY96
MAP2K1
MAPK8IP3
MYD88
NANS
PIK3R1
RAC1
RIPK2
SMAD1
STX17
TGFB1
TICAM1
TIRAP
TLR1
TLR10
TLR6
TMOD1
TOLLIP
TRIP6
164 interacting genes:
ABI2
ADAMTSL4
AQP1
ARNT2
ATN1
ATP23
ATP5PO
ATXN1
AXIN1
BAG3
BCAR1
BEX2
BYSL
C11orf87
CATSPER1
CBLC
CCDC120
CCDC187
CCDC24
CCL5
CEP57L1
CNTF
CREB5
CRYBA4
CTAG2
DHX37
DMRT3
DTX2
EFHC1
EPDR1
ERBB2
EXOC3-AS1
FAM124B
FAM222B
FARS2
FAS
FASLG
FHL3
FOXD4L1
FRS3
GAD1
GATA1
GDPD5
GFI1B
GLIS3
GNAI2
GNE
GPS2
GSE1
HCK
HLA-DPB1
HOXA1
HOXA9
HOXB9
HOXC8
HYKK
IL16
ILF3
INCA1
IP6K3
IQCN
ITGB4
KCTD9
KIF1A
KIR2DL4
KLK15
KPRP
KRTAP26-1
LMO2
LNX1
LPAR2
MAPKBP1
MEMO1
METTL17
MIEN1
MIIP
MISP
MSRB3
MVP
NCK2
NEDD9
NEU4
NOL4L-DT
NR1D2
NSMF
NUP210
ODF1
OIP5
OTUB2
OTX1
PATZ1
PDGFRB
PDLIM4
PER1
PIGS
PIN1
PLEKHN1
POM121
POM121L4P
PPP1R16A
PRKAA1
PRKAA2
PTK2
PTPN13
PTPN14
PXN
RAD23A
RANBP3L
RERE
RFX3
RHOA
RHOQ
RNF213
RNF214
SAXO1
SCAND1
SCRIB
SETDB1
SHISA6
SIK3
SLC15A3
SLC25A6
SMAD1
SMG9
SNAI1
SON
SRC
STAC
STK16
SVIL
SYNGAP1
TAB1
TBC1D22B
TCAF1
TEKT4
TENT5C
THRB
TIE1
TLE5
TLR2
TMSB4X
TPM3
TPM4
TRAF3IP2
TRAPPC2L
TRIM29
TSGA10IP
TSSK3
TTC23
TTLL10
TXN2
TXNDC5
USP2
VASN
VCL
WT1-AS
YPEL3
ZBP1
ZIC1
ZNF541
ZNF580
ZNF581
ZNF688
ZNF785
Entrez ID
7097
7205
HPRD ID
04323
04242
Ensembl ID
ENSG00000137462
ENSG00000087077
Uniprot IDs
A0A0S2Z4S4
B3KWR9
O60603
Q15654
PDB IDs
1FYW
1FYX
1O77
2Z7X
2Z80
6NIG
1X61
2DLO
Enriched GO Terms of Interacting Partners
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