TLR2 and NANS

Data Source:
BioGRID (two hybrid)

		TLR2	NANS
Description		toll like receptor 2	N-acetylneuraminate synthase
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Secretory Granule Membrane Phagocytic Vesicle Membrane Intrinsic Component Of Plasma Membrane Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Cell Projection Cell Body Membrane Raft	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Lipopolysaccharide Binding Amyloid-beta Binding Lipopolysaccharide Immune Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Toll-like Receptor Binding Signaling Receptor Activity Pattern Recognition Receptor Activity Triacyl Lipopeptide Binding Identical Protein Binding Peptidoglycan Binding Protein-containing Complex Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating	N-acylneuraminate Cytidylyltransferase Activity N-acylneuraminate-9-phosphate Synthase Activity N-acetylneuraminate Synthase Activity
	Biological Process	Response To Hypoxia Microglial Cell Activation Cell Activation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Leukotriene Metabolic Process Apoptotic Process Inflammatory Response Immune Response Signal Transduction I-kappaB Phosphorylation Learning Negative Regulation Of Cell Population Proliferation Response To Toxic Substance Positive Regulation Of Gene Expression Microglia Development Positive Regulation Of Wnt Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Central Nervous System Myelin Formation Response To Progesterone Interleukin-10 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Response To Insulin Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Detection Of Triacyl Bacterial Lipopeptide Detection Of Diacyl Bacterial Lipopeptide Neutrophil Degranulation Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Nitric Oxide Metabolic Process Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Inflammatory Response Negative Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Negative Regulation Of Synapse Assembly Response To Fatty Acid Cellular Response To Bacterial Lipopeptide Cellular Response To Lipoteichoic Acid Cellular Response To Interferon-gamma Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Matrix Metallopeptidase Secretion	CMP-N-acetylneuraminate Biosynthetic Process Carbohydrate Biosynthetic Process Glycosylation
Pathways		ER-Phagosome pathway Beta defensins MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor TLR6:TLR2 Cascade MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Neutrophil degranulation Modulation by Mtb of host immune system	Sialic acid metabolism
Drugs		Lyme disease vaccine (recombinant OspA) Adapalene S-(Dimethylarsenic)Cysteine Golotimod Tuberculin purified protein derivative
Diseases
GWAS		Body fat mass ( 28552196)	Alopecia areata ( 25608926) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)
Interacting Genes		29 interacting genes: AKT1 ANP32B CD14 EGFR FBP1 HEMGN HMGB1 HRAS HSP90B1 IRAK1 LY96 MAP2K1 MAPK8IP3 MYD88 NANS PIK3R1 RAC1 RIPK2 SMAD1 STX17 TGFB1 TICAM1 TIRAP TLR1 TLR10 TLR6 TMOD1 TOLLIP TRIP6	19 interacting genes: APC AURKA BCL10 BUB1 CDH1 CTNNA1 EGFR FBXO7 FBXW7 FLCN MCC MLH3 MSH6 ODC1 PDGFRL PTPRJ SRC STK11 TLR2
Entrez ID		7097	54187
HPRD ID		04323	07285
Ensembl ID		ENSG00000137462	ENSG00000095380
Uniprot IDs		A0A0S2Z4S4 B3KWR9 O60603	Q9NR45
PDB IDs		1FYW 1FYX 1O77 2Z7X 2Z80 6NIG	1WVO
Enriched GO Terms of Interacting Partners?
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