TLR2 and TLR6

Data Source:
HPRD (in vivo)

		TLR2	TLR6
Description		toll like receptor 2	toll like receptor 6
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Secretory Granule Membrane Phagocytic Vesicle Membrane Intrinsic Component Of Plasma Membrane Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Cell Projection Cell Body Membrane Raft	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Phagocytic Vesicle Membrane Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex Receptor Complex Membrane Raft
	Molecular Function	Lipopolysaccharide Binding Amyloid-beta Binding Lipopolysaccharide Immune Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Toll-like Receptor Binding Signaling Receptor Activity Pattern Recognition Receptor Activity Triacyl Lipopeptide Binding Identical Protein Binding Peptidoglycan Binding Protein-containing Complex Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Signaling Receptor Binding Protein Binding Toll-like Receptor 2 Binding Signaling Receptor Activity Identical Protein Binding Protein Heterodimerization Activity NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating Lipopeptide Binding
	Biological Process	Response To Hypoxia Microglial Cell Activation Cell Activation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Leukotriene Metabolic Process Apoptotic Process Inflammatory Response Immune Response Signal Transduction I-kappaB Phosphorylation Learning Negative Regulation Of Cell Population Proliferation Response To Toxic Substance Positive Regulation Of Gene Expression Microglia Development Positive Regulation Of Wnt Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Central Nervous System Myelin Formation Response To Progesterone Interleukin-10 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Response To Insulin Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Detection Of Triacyl Bacterial Lipopeptide Detection Of Diacyl Bacterial Lipopeptide Neutrophil Degranulation Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Nitric Oxide Metabolic Process Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Inflammatory Response Negative Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Negative Regulation Of Synapse Assembly Response To Fatty Acid Cellular Response To Bacterial Lipopeptide Cellular Response To Lipoteichoic Acid Cellular Response To Interferon-gamma Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Matrix Metallopeptidase Secretion	Microglial Cell Activation Cell Activation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Gene Expression Interleukin-1 Beta Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-6 Production Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 6 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Detection Of Diacyl Bacterial Lipopeptide Defense Response To Bacterium Positive Regulation Of Macrophage Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JUN Kinase Activity Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Nitric Oxide Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Bacterial Lipopeptide Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Amyloid-beta
Pathways		ER-Phagosome pathway Beta defensins MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor TLR6:TLR2 Cascade MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Neutrophil degranulation Modulation by Mtb of host immune system	ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR6:TLR2 Cascade MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand
Drugs		Lyme disease vaccine (recombinant OspA) Adapalene S-(Dimethylarsenic)Cysteine Golotimod Tuberculin purified protein derivative
Diseases
GWAS		Body fat mass ( 28552196)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic sensitization ( 30013184 23817571) Allergy ( 27182965) Asthma ( 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Helicobacter pylori serologic status ( 23652523) Self-reported allergy ( 23817569)
Interacting Genes		29 interacting genes: AKT1 ANP32B CD14 EGFR FBP1 HEMGN HMGB1 HRAS HSP90B1 IRAK1 LY96 MAP2K1 MAPK8IP3 MYD88 NANS PIK3R1 RAC1 RIPK2 SMAD1 STX17 TGFB1 TICAM1 TIRAP TLR1 TLR10 TLR6 TMOD1 TOLLIP TRIP6	4 interacting genes: BTK HRAS TLR2 TRAP1
Entrez ID		7097	10333
HPRD ID		04323	05656
Ensembl ID		ENSG00000137462	ENSG00000174130
Uniprot IDs		A0A0S2Z4S4 B3KWR9 O60603	B2R933 Q9Y2C9
PDB IDs		1FYW 1FYX 1O77 2Z7X 2Z80 6NIG	4OM7
Enriched GO Terms of Interacting Partners?
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