THY1 and HTR6

Data Source:
BioGRID (two hybrid)

		THY1	HTR6
Description		Thy-1 cell surface antigen	5-hydroxytryptamine receptor 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Apical Plasma Membrane Dendrite Growth Cone Axolemma Anchored Component Of External Side Of Plasma Membrane Dendrite Membrane Neuronal Cell Body Membrane Membrane Raft Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Cilium Dendrite Synapse
	Molecular Function	GTPase Activator Activity Integrin Binding Protein Binding Protein Kinase Binding GPI Anchor Binding	Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity
	Biological Process	Angiogenesis Regulation Of Cell-matrix Adhesion Positive Regulation Of Cellular Extravasation Negative Regulation Of Protein Kinase Activity Cytoskeleton Organization Integrin-mediated Signaling Pathway Cell-cell Signaling Negative Regulation Of Cell Migration Positive Regulation Of Heterotypic Cell-cell Adhesion Receptor Clustering Positive Regulation Of GTPase Activity Retinal Cone Cell Development Focal Adhesion Assembly Negative Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Neuron Projection Regeneration Cell-cell Adhesion Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Cerebral Cortex Cell Migration Positive Regulation Of TOR Signaling G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Serotonin receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Ziprasidone Amitriptyline Olanzapine Clozapine Loxapine Imipramine Chlorpromazine Haloperidol Amoxapine Paroxetine Cyclobenzaprine Ergoloid mesylate Doxepin Quetiapine Aripiprazole Chlorprothixene Dimethyltryptamine Lysergic acid diethylamide Iloperidone SGS518 PRX-07034 SUVN-502 Sertindole Mianserin Asenapine Zotepine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Refractive error ( 32231278)	Chronotype ( 26955885 27494321) Morning person ( 30696823) Morning vs. evening chronotype ( 26955885 27494321)
Interacting Genes		10 interacting genes: ATXN1L ATXN7 CCR8 CLK1 FYN HTR6 ITGAM ITGAV ITGB3 LCK	31 interacting genes: ABCA2 ACTB AIP AKR1A1 AP2M1 AP4S1 ATXN10 CHN1 CMSS1 COPS5 DDRGK1 DHRS1 EIF4A3 FYN GNAQ GNAS HDGFL2 IDS MAP1B NF1 NRXN3 PARP8 RUNDC3A SCHIP1 SLC6A1 SRRT SYT5 THY1 TMEM98 TTYH1 UQCRFS1
Entrez ID		7070	3362
HPRD ID		01769	03066
Ensembl ID		ENSG00000154096	ENSG00000158748
Uniprot IDs		B0YJA4 P04216	P50406
PDB IDs
Enriched GO Terms of Interacting Partners?
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