TFAP2C and CITED2

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		TFAP2C	CITED2
Description		transcription factor AP-2 gamma	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Mitochondrion Cytosol	Chromatin Nucleus Nucleoplasm Protein-containing Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Histone Acetyltransferase Binding LBD Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell-cell Signaling Male Gonad Development Regulation Of Gene Expression, Epigenetic Regulation Of Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Development	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Liver Development Outflow Tract Morphogenesis Regulation Of Animal Organ Formation Determination Of Left/right Symmetry Heart Development Sex Determination Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Cell Differentiation Negative Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Fluid Shear Stress Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Adrenal Cortex Formation Negative Regulation Of Apoptotic Process Response To Estrogen Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Ventricular Septum Morphogenesis Embryonic Heart Tube Left/right Pattern Formation Left/right Pattern Formation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Left/right Axis Specification Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Positive Regulation Of Male Gonad Development
Pathways		SUMOylation of transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors TFAP2 (AP-2) family regulates transcription of other transcription factors Activation of the TFAP2 (AP-2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors TFAP2 (AP-2) family regulates transcription of cell cycle factors	Regulation of gene expression by Hypoxia-inducible Factor TFAP2 (AP-2) family regulates transcription of other transcription factors Activation of the TFAP2 (AP-2) family of transcription factors FOXO-mediated transcription of cell death genes
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Blood urea nitrogen levels ( 31152163) Cerebrospinal P-tau181p levels ( 28247064) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Cognitive decline rate in late mild cognitive impairment ( 26252872) Maximum stenosis ( 32469969) Mean degree of stenosis ( 32469969) Ovarian cancer ( 30557369) Refractive error ( 32231278) Sum of stenosis ( 32469969)	Albumin-globulin ratio ( 29403010) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Blood trace element (Se levels) ( 23720494) Caudate volume in trauma-exposed individuals ( 29187748) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 30224653) Glycated hemoglobin levels ( 28898252) HDL cholesterol ( 24097068 20686565) HDL cholesterol levels ( 32203549 28334899) IgA levels ( 28628107) Mean corpuscular hemoglobin ( 23263863 28453575 20139978 28017375 19862010) Mean corpuscular volume ( 23263863 32888494 28453575 20139978 28017375 19862010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Non-albumin protein levels ( 29403010) Obesity-related traits ( 23251661) Red blood cell traits ( 23222517) Systolic blood pressure ( 30224653) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Triglyceride levels ( 32203549) Triglycerides ( 25961943) Urate levels in lean individuals ( 25811787)
Interacting Genes		12 interacting genes: CCNG1 CITED1 CITED2 CITED4 ERBB4 GPR22 IKBKB NR1I2 TP53 UBE2I WWOX ZFAND4	11 interacting genes: CREBBP EP300 FBXL5 HIF1A LHX2 LHX3 MAPK1 TBP TFAP2A TFAP2B TFAP2C
Entrez ID		7022	10370
HPRD ID		03361	04245
Ensembl ID		ENSG00000087510	ENSG00000164442
Uniprot IDs		Q92754	A0A0A0MTM3 D9ZGF1 Q99967
PDB IDs			1P4Q 1R8U
Enriched GO Terms of Interacting Partners?
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