CITED2 and LHX2

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)
HPRD (in vitro, in vivo, two hybrid)

		CITED2	LHX2
Description		Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2	LIM homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Protein-containing Complex	Chromatin Nucleus
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Histone Acetyltransferase Binding LBD Domain Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Liver Development Outflow Tract Morphogenesis Regulation Of Animal Organ Formation Determination Of Left/right Symmetry Heart Development Sex Determination Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Cell Differentiation Negative Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Fluid Shear Stress Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Adrenal Cortex Formation Negative Regulation Of Apoptotic Process Response To Estrogen Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Ventricular Septum Morphogenesis Embryonic Heart Tube Left/right Pattern Formation Left/right Pattern Formation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Left/right Axis Specification Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Positive Regulation Of Male Gonad Development	Regulation Of Transcription By RNA Polymerase II Neuron Differentiation Positive Regulation Of Transcription, DNA-templated
Pathways		Regulation of gene expression by Hypoxia-inducible Factor TFAP2 (AP-2) family regulates transcription of other transcription factors Activation of the TFAP2 (AP-2) family of transcription factors FOXO-mediated transcription of cell death genes	Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Blood trace element (Se levels) ( 23720494) Caudate volume in trauma-exposed individuals ( 29187748) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 30224653) Glycated hemoglobin levels ( 28898252) HDL cholesterol ( 24097068 20686565) HDL cholesterol levels ( 32203549 28334899) IgA levels ( 28628107) Mean corpuscular hemoglobin ( 23263863 28453575 20139978 28017375 19862010) Mean corpuscular volume ( 23263863 32888494 28453575 20139978 28017375 19862010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Non-albumin protein levels ( 29403010) Obesity-related traits ( 23251661) Red blood cell traits ( 23222517) Systolic blood pressure ( 30224653) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Triglyceride levels ( 32203549) Triglycerides ( 25961943) Urate levels in lean individuals ( 25811787)	Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Blond vs. brown/black hair color ( 30531825) Depression ( 29700475) Hair color ( 29662168) Mercury levels ( 26025379) Post-traumatic stress disorder ( 25456346) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Waist circumference ( 23966867)
Interacting Genes		11 interacting genes: CREBBP EP300 FBXL5 HIF1A LHX2 LHX3 MAPK1 TBP TFAP2A TFAP2B TFAP2C	28 interacting genes: ANKS1A ARHGAP32 BEND2 CITED2 DNMT3L FLYWCH1 HOMER3 HOXC8 KHK LDB1 LGALSL LNX1 LONRF1 MORF4L1 MORN3 MSX1 OSMR PAX6 POU4F2 PPIL1 RLIM TCEANC TCP11L1 TLK1 TRAPPC2L UBTFL1 ZFP42 ZNF511
Entrez ID		10370	9355
HPRD ID		04245	04786
Ensembl ID		ENSG00000164442	ENSG00000106689
Uniprot IDs		A0A0A0MTM3 D9ZGF1 Q99967	B3KNJ5 P50458
PDB IDs		1P4Q 1R8U
Enriched GO Terms of Interacting Partners?
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