TFAP2C and CITED4

Data Source:
HPRD (in vitro)

		TFAP2C	CITED4
Description		transcription factor AP-2 gamma	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Mitochondrion Cytosol	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Transcription Coactivator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell-cell Signaling Male Gonad Development Regulation Of Gene Expression, Epigenetic Regulation Of Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Development	Response To Estrogen Positive Regulation Of Transcription By RNA Polymerase II
Pathways		SUMOylation of transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors TFAP2 (AP-2) family regulates transcription of other transcription factors Activation of the TFAP2 (AP-2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors TFAP2 (AP-2) family regulates transcription of cell cycle factors	Activation of the TFAP2 (AP-2) family of transcription factors
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Blood urea nitrogen levels ( 31152163) Cerebrospinal P-tau181p levels ( 28247064) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Cognitive decline rate in late mild cognitive impairment ( 26252872) Maximum stenosis ( 32469969) Mean degree of stenosis ( 32469969) Ovarian cancer ( 30557369) Refractive error ( 32231278) Sum of stenosis ( 32469969)
Interacting Genes		12 interacting genes: CCNG1 CITED1 CITED2 CITED4 ERBB4 GPR22 IKBKB NR1I2 TP53 UBE2I WWOX ZFAND4	4 interacting genes: EP300 TFAP2A TFAP2B TFAP2C
Entrez ID		7022	163732
HPRD ID		03361	06011
Ensembl ID		ENSG00000087510	ENSG00000179862
Uniprot IDs		Q92754	Q96RK1
PDB IDs
Enriched GO Terms of Interacting Partners?
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