PRDX2 and CD320

Data Source:
BioGRID (two hybrid)

		PRDX2	CD320
Description		peroxiredoxin 2	CD320 molecule
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GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Membrane
	Molecular Function	Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity	Calcium Ion Binding Protein Binding Growth Factor Activity ABC-type Vitamin B12 Transporter Activity Cobalamin Binding
	Biological Process	Activation Of MAPK Activity Respiratory Burst Involved In Inflammatory Response Response To Oxidative Stress Regulation Of Hydrogen Peroxide Metabolic Process Removal Of Superoxide Radicals Positive Regulation Of Blood Coagulation Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Lipopolysaccharide Cellular Response To Stress Cellular Response To Oxidative Stress T Cell Proliferation Hydrogen Peroxide Catabolic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Leukocyte Activation Cell Redox Homeostasis Negative Regulation Of T Cell Differentiation Thymus Development Homeostasis Of Number Of Cells Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Signal Transduction Cobalamin Metabolic Process Cobalamin Transport Positive Regulation Of B Cell Proliferation B Cell Costimulation
Pathways		Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Cobalamin (Cbl, vitamin B12) transport and metabolism Defective CD320 causes methylmalonic aciduria
Drugs		3-sulfino-L-alanine N-Carbamoyl-Alanine Copper
Diseases
GWAS		Platelet distribution width ( 32888494)	Obsessive-compulsive disorder ( 30456828)
Interacting Genes		24 interacting genes: A2M APOE APP BAD CA4 CD320 CDC37 COPS5 ECSIT EXOC6 IFIT5 MAST1 NLGN3 PDGFRB PPP2R1A PPP2R1B PRDX4 PSEN1 RNF32 SAT1 SUMO4 TXNDC5 UTY YWHAZ	1 interacting genes: PRDX2
Entrez ID		7001	51293
HPRD ID		02763	05929
Ensembl ID		ENSG00000167815	ENSG00000167775
Uniprot IDs		P32119 V9HW12	Q9NPF0
PDB IDs		1QMV 5B8A 5B8B 5IJT	4ZRP 4ZRQ
Enriched GO Terms of Interacting Partners?
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