PRDX2 and TXNDC5

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		PRDX2	TXNDC5
Description		peroxiredoxin 2	thioredoxin domain containing 5
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity	Protein Disulfide Isomerase Activity Protein Binding
	Biological Process	Activation Of MAPK Activity Respiratory Burst Involved In Inflammatory Response Response To Oxidative Stress Regulation Of Hydrogen Peroxide Metabolic Process Removal Of Superoxide Radicals Positive Regulation Of Blood Coagulation Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Lipopolysaccharide Cellular Response To Stress Cellular Response To Oxidative Stress T Cell Proliferation Hydrogen Peroxide Catabolic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Leukocyte Activation Cell Redox Homeostasis Negative Regulation Of T Cell Differentiation Thymus Development Homeostasis Of Number Of Cells Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Protein Phosphopantetheinylation Negative Regulation Of Apoptotic Process Apoptotic Cell Clearance Neutrophil Degranulation
Pathways		Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation
Drugs		3-sulfino-L-alanine N-Carbamoyl-Alanine Copper
Diseases
GWAS		Platelet distribution width ( 32888494)	Blood protein levels ( 30072576 29875488) High chromosomal aberration frequency (chromatid type) ( 31586183) Mean corpuscular hemoglobin ( 32888494) Pelvic organ prolapse ( 32184442)
Interacting Genes		24 interacting genes: A2M APOE APP BAD CA4 CD320 CDC37 COPS5 ECSIT EXOC6 IFIT5 MAST1 NLGN3 PDGFRB PPP2R1A PPP2R1B PRDX4 PSEN1 RNF32 SAT1 SUMO4 TXNDC5 UTY YWHAZ	27 interacting genes: APP AR BLZF1 EDEM3 EFEMP1 FLACC1 GMPPB KRT38 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-12 KRTAP4-2 LHX4 MGAT5B NOTCH2NLA PJA1 PRDX2 RAB3IP SPRY2 TRIM23 TRIM42 TRIP6 UBQLN2
Entrez ID		7001	81567
HPRD ID		02763	18249
Ensembl ID		ENSG00000167815	ENSG00000239264
Uniprot IDs		P32119 V9HW12	A0A024QZV0 Q8NBS9
PDB IDs		1QMV 5B8A 5B8B 5IJT	2DIZ 3UJ1 3UVT 3WGD 3WGE 3WGX
Enriched GO Terms of Interacting Partners?
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