CD320 and PRDX2

Data Source:
BioGRID (two hybrid)

		CD320	PRDX2
Description		CD320 molecule	peroxiredoxin 2
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GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Membrane	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Growth Factor Activity ABC-type Vitamin B12 Transporter Activity Cobalamin Binding	Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity
	Biological Process	Signal Transduction Cobalamin Metabolic Process Cobalamin Transport Positive Regulation Of B Cell Proliferation B Cell Costimulation	Activation Of MAPK Activity Respiratory Burst Involved In Inflammatory Response Response To Oxidative Stress Regulation Of Hydrogen Peroxide Metabolic Process Removal Of Superoxide Radicals Positive Regulation Of Blood Coagulation Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Lipopolysaccharide Cellular Response To Stress Cellular Response To Oxidative Stress T Cell Proliferation Hydrogen Peroxide Catabolic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Leukocyte Activation Cell Redox Homeostasis Negative Regulation Of T Cell Differentiation Thymus Development Homeostasis Of Number Of Cells Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Cobalamin (Cbl, vitamin B12) transport and metabolism Defective CD320 causes methylmalonic aciduria	Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs			3-sulfino-L-alanine N-Carbamoyl-Alanine Copper
Diseases
GWAS		Obsessive-compulsive disorder ( 30456828)	Platelet distribution width ( 32888494)
Interacting Genes		1 interacting genes: PRDX2	24 interacting genes: A2M APOE APP BAD CA4 CD320 CDC37 COPS5 ECSIT EXOC6 IFIT5 MAST1 NLGN3 PDGFRB PPP2R1A PPP2R1B PRDX4 PSEN1 RNF32 SAT1 SUMO4 TXNDC5 UTY YWHAZ
Entrez ID		51293	7001
HPRD ID		05929	02763
Ensembl ID		ENSG00000167775	ENSG00000167815
Uniprot IDs		Q9NPF0	P32119 V9HW12
PDB IDs		4ZRP 4ZRQ	1QMV 5B8A 5B8B 5IJT
Enriched GO Terms of Interacting Partners?
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