ACTC1 and KLHL17

Data Source:
HPRD (in vivo)

		ACTC1	KLHL17
Description		actin alpha cardiac muscle 1	kelch like family member 17
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Dynactin Complex Actin Filament Focal Adhesion Membrane Sarcomere Lamellipodium Filopodium I Band Cell Body Extracellular Exosome Blood Microparticle	Extracellular Space Postsynaptic Density Actin Cytoskeleton Dendrite Cytoplasm Neuronal Cell Body
	Molecular Function	ATP Binding ATPase Activity Myosin Binding	Protein Binding POZ Domain Binding Actin Filament Binding Molecular Adaptor Activity
	Biological Process	Actin Filament Organization Positive Regulation Of Gene Expression Actin Filament-based Movement Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Response To Drug Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Mesenchyme Migration	Brain Development Protein Ubiquitination Actin Cytoskeleton Organization
Pathways		Striated Muscle Contraction
Drugs
Diseases		Hypertrophic cardiomyopathy (HCM) Atrial septal defect Dilated cardiomyopathy (DCM)
GWAS		Axial length ( 24144296) Refractive error ( 32231278 20835239)	Anorectal malformation ( 31136621) Heel bone mineral density ( 30598549) Lysophosphatidylethanolamine levels ( 31551469)
Interacting Genes		41 interacting genes: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG ASH2L BCL11A C1QTNF9 CAPN1 CFL1 DMD DMTN DYNLL1 EZR FBXO7 FSCN1 GAPDH GC HSPB1 HSPB2 KAT14 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 UBC WAS WIPF1	1 interacting genes: ACTC1
Entrez ID		70	339451
HPRD ID		00015	13926
Ensembl ID		ENSG00000159251	ENSG00000187961
Uniprot IDs		B3KPP5 P68032	Q6TDP4
PDB IDs			6HRL
Enriched GO Terms of Interacting Partners?
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