KLHL17 and ACTC1

Data Source:
HPRD (in vivo)

		KLHL17	ACTC1
Description		kelch like family member 17	actin alpha cardiac muscle 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Postsynaptic Density Actin Cytoskeleton Dendrite Cytoplasm Neuronal Cell Body	Extracellular Space Cytoplasm Cytosol Dynactin Complex Actin Filament Focal Adhesion Membrane Sarcomere Lamellipodium Filopodium I Band Cell Body Extracellular Exosome Blood Microparticle
	Molecular Function	Protein Binding POZ Domain Binding Actin Filament Binding Molecular Adaptor Activity	ATP Binding ATPase Activity Myosin Binding
	Biological Process	Brain Development Protein Ubiquitination Actin Cytoskeleton Organization	Actin Filament Organization Positive Regulation Of Gene Expression Actin Filament-based Movement Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Response To Drug Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Mesenchyme Migration
Pathways			Striated Muscle Contraction
Drugs
Diseases			Hypertrophic cardiomyopathy (HCM) Atrial septal defect Dilated cardiomyopathy (DCM)
GWAS		Anorectal malformation ( 31136621) Heel bone mineral density ( 30598549) Lysophosphatidylethanolamine levels ( 31551469)	Axial length ( 24144296) Refractive error ( 32231278 20835239)
Interacting Genes		1 interacting genes: ACTC1	41 interacting genes: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG ASH2L BCL11A C1QTNF9 CAPN1 CFL1 DMD DMTN DYNLL1 EZR FBXO7 FSCN1 GAPDH GC HSPB1 HSPB2 KAT14 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 UBC WAS WIPF1
Entrez ID		339451	70
HPRD ID		13926	00015
Ensembl ID		ENSG00000187961	ENSG00000159251
Uniprot IDs		Q6TDP4	B3KPP5 P68032
PDB IDs		6HRL
Enriched GO Terms of Interacting Partners?
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