BUB1 and CYLC2

Data Source:
BioGRID (two hybrid)

		BUB1	CYLC2
Description		BUB1 mitotic checkpoint serine/threonine kinase	cylicin 2
Image			No pdb structure
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Kinetochore Condensed Nuclear Chromosome Outer Kinetochore Nucleoplasm Cytosol Membrane Intracellular Membrane-bounded Organelle	Nucleus Cytoskeletal Calyx
	Molecular Function	Protein Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Structural Constituent Of Cytoskeleton
	Biological Process	Protein Phosphorylation Apoptotic Process Regulation Of Sister Chromatid Cohesion Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Cell Population Proliferation Viral Process Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Chromosome Segregation	Cytoskeleton Organization Multicellular Organism Development Spermatogenesis Cell Differentiation
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		63 interacting genes: AKT1 ALDOB ANP32B AOPEP AP1B1 AP2B1 AP3B1 AP4B1 APC ARIH2 BAAT BUB3 CCDC180 CDC14B CDC20 CDK1 CDK8 CORO2A CRK CTSV CYLC2 DVL1 EIF4EBP1 FANCC FBP1 FBP2 FBXO7 FRAT2 GALNT12 HDAC1 HEMGN HRAS HSD17B3 IGFBP3 KNL1 LEF1 MAP2K1 MAPK3 MSANTD3 NANS PLK1 PPP2CB PPP3R2 RAE1 RASA1 RDH12 SEC61B SFRP2 SFRP4 SHC1 SMAD1 STX17 SVIL TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRMO TSTD2 XPA ZNF189 ZNF510	13 interacting genes: AURKA BUB1 CDKN2A EGFR ERBB2 MAP2K4 MCC MLH1 MLH3 MUTYH NRAS SMAD2 STK11
Entrez ID		699	1539
HPRD ID		03907	04945
Ensembl ID		ENSG00000169679	ENSG00000155833
Uniprot IDs		B4DYG2 O43683	A0A024R146 Q14093 Q6PEJ5
PDB IDs		2LAH 4A1G 4QPM 4R8Q 5DMZ 6F7B
Enriched GO Terms of Interacting Partners?
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