BUB1 and NANS

Data Source:
BioGRID (two hybrid)

		BUB1	NANS
Description		BUB1 mitotic checkpoint serine/threonine kinase	N-acetylneuraminate synthase
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GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Kinetochore Condensed Nuclear Chromosome Outer Kinetochore Nucleoplasm Cytosol Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	N-acylneuraminate Cytidylyltransferase Activity N-acylneuraminate-9-phosphate Synthase Activity N-acetylneuraminate Synthase Activity
	Biological Process	Protein Phosphorylation Apoptotic Process Regulation Of Sister Chromatid Cohesion Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Cell Population Proliferation Viral Process Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Chromosome Segregation	CMP-N-acetylneuraminate Biosynthetic Process Carbohydrate Biosynthetic Process Glycosylation
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Sialic acid metabolism
Drugs
Diseases
GWAS			Alopecia areata ( 25608926) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)
Interacting Genes		63 interacting genes: AKT1 ALDOB ANP32B AOPEP AP1B1 AP2B1 AP3B1 AP4B1 APC ARIH2 BAAT BUB3 CCDC180 CDC14B CDC20 CDK1 CDK8 CORO2A CRK CTSV CYLC2 DVL1 EIF4EBP1 FANCC FBP1 FBP2 FBXO7 FRAT2 GALNT12 HDAC1 HEMGN HRAS HSD17B3 IGFBP3 KNL1 LEF1 MAP2K1 MAPK3 MSANTD3 NANS PLK1 PPP2CB PPP3R2 RAE1 RASA1 RDH12 SEC61B SFRP2 SFRP4 SHC1 SMAD1 STX17 SVIL TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRMO TSTD2 XPA ZNF189 ZNF510	19 interacting genes: APC AURKA BCL10 BUB1 CDH1 CTNNA1 EGFR FBXO7 FBXW7 FLCN MCC MLH3 MSH6 ODC1 PDGFRL PTPRJ SRC STK11 TLR2
Entrez ID		699	54187
HPRD ID		03907	07285
Ensembl ID		ENSG00000169679	ENSG00000095380
Uniprot IDs		B4DYG2 O43683	Q9NR45
PDB IDs		2LAH 4A1G 4QPM 4R8Q 5DMZ 6F7B	1WVO
Enriched GO Terms of Interacting Partners?
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