ADAM17 and PTPN3

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		ADAM17	PTPN3
Description		ADAM metallopeptidase domain 17	protein tyrosine phosphatase non-receptor type 3
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Focal Adhesion Cell Surface Actin Cytoskeleton Membrane Apical Plasma Membrane Ruffle Membrane Membrane Raft	Cytoplasm Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Notch Binding Interleukin-6 Receptor Binding Integrin Binding Protein Binding Peptidase Activity Metallopeptidase Activity SH3 Domain Binding PDZ Domain Binding Metal Ion Binding Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process	Phosphotyrosine Residue Binding Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Sodium Channel Regulator Activity ATPase Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Neutrophil Mediated Immunity Germinal Center Formation Positive Regulation Of Leukocyte Chemotaxis Proteolysis Membrane Protein Ectodomain Proteolysis Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Notch Receptor Processing Positive Regulation Of Cell Population Proliferation Positive Regulation Of T Cell Chemotaxis Protein Processing B Cell Differentiation Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Membrane Protein Intracellular Domain Proteolysis Response To Lipopolysaccharide Positive Regulation Of Chemokine Production Regulation Of Mast Cell Apoptotic Process T Cell Differentiation In Thymus Tumor Necrosis Factor-mediated Signaling Pathway Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Epidermal Cells Receptor Transactivation Response To Drug Amyloid Precursor Protein Catabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Spleen Development Cell Motility Defense Response To Gram-positive Bacterium Positive Regulation Of Cellular Component Movement Cellular Response To High Density Lipoprotein Particle Stimulus Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Vascular Endothelial Cell Proliferation	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Membrane Protein Ectodomain Proteolysis Liver Regeneration Regulation Of Membrane Depolarization During Action Potential Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Nuclear signaling by ERBB4 Collagen degradation Signaling by EGFR Regulated proteolysis of p75NTR Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Release of Hh-Np from the secreting cell TNF signaling CD163 mediating an anti-inflammatory response Growth hormone receptor signaling	EGFR downregulation Negative regulation of MAPK pathway
Drugs		(3S)-1-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}pyrrolidine-3-thiol 3-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}propane-1-thiol 4-({4-[(4-AMINOBUT-2-YNYL)OXY]PHENYL}SULFONYL)-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE (2R)-N-HYDROXY-2-[(3S)-3-METHYL-3-{4-[(2-METHYLQUINOLIN-4-YL)METHOXY]PHENYL}-2-OXOPYRROLIDIN-1-YL]PROPANAMIDE methyl (1R,2S)-2-(hydroxycarbamoyl)-1-{4-[(2-methylquinolin-4-yl)methoxy]benzyl}cyclopropanecarboxylate (1S,3R,6S)-4-oxo-6-{4-[(2-phenylquinolin-4-yl)methoxy]phenyl}-5-azaspiro[2.4]heptane-1-carboxylic acid N-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}-5-methyl-D-tryptophan (3S)-4-{[4-(BUT-2-YNYLOXY)PHENYL]SULFONYL}-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE
Diseases
GWAS		Birth weight ( 31043758) Offspring birth weight ( 31043758)	Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) HIV-associated neurocognitive disorder ( 28447399) HIV-associated neurocognitive disorder (asymptomatic neurocogntive impairment) ( 28447399) HIV-associated neurocognitive disorder (mild neurocognitive disorder or asymptomatic neurocognitive impairment) ( 28447399) Iris color (a* coordinate) ( 30895295) Iris color (b* coordinate) ( 30895295) Red blood cell density in sickle cell anemia ( 28552477) Serum albumin level ( 29403010) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Triglyceride levels ( 32203549)
Interacting Genes		14 interacting genes: DLG1 ERBB4 FHL2 MAD2L1 MAD2L2 NOTCH1 PTPN3 SH3D19 TGFA TIMP3 TNF TNFRSF1A TNFRSF1B TNFSF11	26 interacting genes: ADAM17 AKR1C1 AKT1 CD247 DIP2A GHR HSPB1 LMO1 MAPK12 MLH1 MTMR9 NXT2 PLEKHF2 RNF111 RPS6KA1 TENT5D TFAP4 TRIM41 VCP VWA2 WDR6 YWHAB YWHAG YWHAQ ZAP70 ZCCHC10
Entrez ID		6868	5774
HPRD ID		04703	06767
Ensembl ID		ENSG00000151694	ENSG00000070159
Uniprot IDs		B2RNB2 P78536	B7Z3V3 B7Z9V1 B7ZA03 P26045 Q8N4S3
PDB IDs		1BKC 1ZXC 2A8H 2DDF 2FV5 2FV9 2I47 2M2F 2OI0 3B92 3CKI 3E8R 3EDZ 3EWJ 3G42 3KMC 3KME 3L0T 3L0V 3LE9 3LEA 3LGP 3O64	2B49 4QUM 4QUN 4RH5 4RH9 4RHG 4RI4 4RI5 4S0G 6HKS
Enriched GO Terms of Interacting Partners?
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