PTPN3 and AKR1C1

Data Source:
BioGRID (two hybrid)

		PTPN3	AKR1C1
Description		protein tyrosine phosphatase non-receptor type 3	aldo-keto reductase family 1 member C1
Image
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane	Cytosol Extracellular Exosome
	Molecular Function	Phosphotyrosine Residue Binding Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Sodium Channel Regulator Activity ATPase Binding	Alditol:NADP+ 1-oxidoreductase Activity Aldo-keto Reductase (NADP) Activity Estradiol 17-beta-dehydrogenase Activity Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Phenanthrene 9,10-monooxygenase Activity Testosterone Dehydrogenase [NAD(P)] Activity Carboxylic Acid Binding Bile Acid Binding Dihydrotestosterone 17-beta-dehydrogenase Activity 17-alpha,20-alpha-dihydroxypregn-4-en-3-one Dehydrogenase Activity Androsterone Dehydrogenase Activity 5alpha-androstane-3beta,17beta-diol Dehydrogenase Activity Androsterone Dehydrogenase (B-specific) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase Activity Ketosteroid Monooxygenase Activity Trans-1,2-dihydrobenzene-1,2-diol Dehydrogenase Activity Indanol Dehydrogenase Activity
	Biological Process	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Membrane Protein Ectodomain Proteolysis Liver Regeneration Regulation Of Membrane Depolarization During Action Potential Regulation Of Sodium Ion Transmembrane Transporter Activity	Retinoid Metabolic Process Prostaglandin Metabolic Process Xenobiotic Metabolic Process Digestion Steroid Metabolic Process Bile Acid Metabolic Process Bile Acid And Bile Salt Transport Intestinal Cholesterol Absorption Epithelial Cell Differentiation Progesterone Metabolic Process Retinal Metabolic Process Cholesterol Homeostasis Daunorubicin Metabolic Process Doxorubicin Metabolic Process Response To Organophosphorus Cellular Response To Jasmonic Acid Stimulus
Pathways		EGFR downregulation Negative regulation of MAPK pathway	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Retinoid metabolism and transport
Drugs			NADH Salicylic acid Acetylsalicylic acid Nicotinamide adenine dinucleotide phosphate Naringenin 2-HYDROXY-3,5-DIIODOBENZOIC ACID Epitestosterone Hexestrol
Diseases
GWAS		Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) HIV-associated neurocognitive disorder ( 28447399) HIV-associated neurocognitive disorder (asymptomatic neurocogntive impairment) ( 28447399) HIV-associated neurocognitive disorder (mild neurocognitive disorder or asymptomatic neurocognitive impairment) ( 28447399) Iris color (a* coordinate) ( 30895295) Iris color (b* coordinate) ( 30895295) Red blood cell density in sickle cell anemia ( 28552477) Serum albumin level ( 29403010) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Triglyceride levels ( 32203549)	Blood protein levels ( 29875488) Economic and political preferences (immigration/crime) ( 22566634) Height ( 25282103) Hypopharyngeal or laryngeal cancer ( 32276964) Lung cancer ( 28604730) Metabolite levels ( 23823483) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		26 interacting genes: ADAM17 AKR1C1 AKT1 CD247 DIP2A GHR HSPB1 LMO1 MAPK12 MLH1 MTMR9 NXT2 PLEKHF2 RNF111 RPS6KA1 TENT5D TFAP4 TRIM41 VCP VWA2 WDR6 YWHAB YWHAG YWHAQ ZAP70 ZCCHC10	3 interacting genes: COMMD8 MAPK3 PTPN3
Entrez ID		5774	1645
HPRD ID		06767	07194
Ensembl ID		ENSG00000070159	ENSG00000187134
Uniprot IDs		B7Z3V3 B7Z9V1 B7ZA03 P26045 Q8N4S3	Q04828
PDB IDs		2B49 4QUM 4QUN 4RH5 4RH9 4RHG 4RI4 4RI5 4S0G 6HKS	1MRQ 3C3U 3GUG 3NTY 4YVP 6A7A 6IJX
Enriched GO Terms of Interacting Partners?
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