ADAM17 and TNFSF11

  • Data Source:
  • HPRD (in vivo)

ADAM17

TNFSF11

Description ADAM metallopeptidase domain 17 TNF superfamily member 11
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GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359)
  • Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359)
  • Allergic rhinitis ( 30013184)
  • Arthritis (juvenile idiopathic) ( 33106285)
  • Asthma (childhood onset) ( 30929738)
  • Bone mineral density ( 24249740 23437003)
  • Bone mineral density (paediatric, total body less head) ( 24945404)
  • Bone mineral density (paediatric, upper limb) ( 24945404)
  • C-reactive protein levels ( 24763700)
  • Cortical thickness ( 22792071)
  • Crohn's disease ( 21102463)
  • Heel bone mineral density ( 30598549)
  • Lumbar spine bone mineral density (integral) ( 27476799)
  • Lumbar spine bone mineral density (trabecular) ( 27476799)
  • Serum alkaline phosphatase levels ( 29403010)
  • Vitiligo ( 27723757)
Interacting Genes 14 interacting genes: DLG1 ERBB4 FHL2 MAD2L1 MAD2L2 NOTCH1 PTPN3 SH3D19 TGFA TIMP3 TNF TNFRSF1A TNFRSF1B TNFSF11 32 interacting genes: ADAM17 ADAM19 AKT1 BBS10 CEP126 DDAH2 EEF1A1 EZH2 LMO4 MAPK1 MAPK3 MAPK8 MBTPS1 MED24 MMP1 MMP3 MMP7 NFKB1 NFKBIA OLFM4 PHAX PLK1 PRXL2B SBF1 SNRNP35 TMOD3 TNFRSF11A TNFRSF11B TRAF6 TRMT2A UPK2 ZC3HC1
Entrez ID 6868 8600
HPRD ID 04703 04031
Ensembl ID ENSG00000151694 ENSG00000120659
Uniprot IDs B2RNB2 P78536 O14788 Q54A98 Q5T9Y4
PDB IDs 1BKC 1ZXC 2A8H 2DDF 2FV5 2FV9 2I47 2M2F 2OI0 3B92 3CKI 3E8R 3EDZ 3EWJ 3G42 3KMC 3KME 3L0T 3L0V 3LE9 3LEA 3LGP 3O64 3URF 5BNQ
Enriched GO Terms of Interacting Partners?
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