STYX and MUSK

Data Source:
BioGRID (two hybrid)

		STYX	MUSK
Description		serine/threonine/tyrosine interacting protein	muscle associated receptor tyrosine kinase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Integral Component Of Plasma Membrane Neuromuscular Junction Receptor Complex Postsynaptic Membrane
	Molecular Function	Pseudophosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity F-box Domain Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding Collagen Binding ATP Binding Protein Tyrosine Kinase Collagen Receptor Activity Metal Ion Binding
	Biological Process	Protein Dephosphorylation Negative Regulation Of Protein Binding Negative Regulation Of Catalytic Activity MAPK Export From Nucleus Negative Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Regulation Of ERK1 And ERK2 Cascade	Positive Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Neuromuscular Junction Development Memory Regulation Of Synaptic Growth At Neuromuscular Junction Positive Regulation Of Gene Expression Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Kinase Activity Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Protein Autophosphorylation Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Protein Geranylgeranylation
Pathways			ECM proteoglycans
Drugs			Fostamatinib
Diseases			Congenital myasthenic syndrome
GWAS		Prostate cancer ( 23535732)	Body mass index ( 28552196) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Pulmonary function decline ( 22424883) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)
Interacting Genes		24 interacting genes: AATK CARHSP1 EGFR EPHA2 EPHA3 EPHA7 EPHB6 ERBB2 ERBB3 ERBB4 FBXO7 FBXW7 IGF1R INSR INSRR KDR KIT LMTK2 MAPK1 MUSK PTK7 ROR1 ROR2 TEK	7 interacting genes: COLQ DOK7 ERBIN ILKAP RAPSN STYX SYNE1
Entrez ID		6815	4593
HPRD ID		10258	03190
Ensembl ID		ENSG00000198252	ENSG00000030304
Uniprot IDs		A0A024R641 Q8WUJ0	A0A087WSY1 O15146
PDB IDs		2R0B
Enriched GO Terms of Interacting Partners?
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