MUSK and STYX

Data Source:
BioGRID (two hybrid)

		MUSK	STYX
Description		muscle associated receptor tyrosine kinase	serine/threonine/tyrosine interacting protein
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Plasma Membrane Neuromuscular Junction Receptor Complex Postsynaptic Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding Collagen Binding ATP Binding Protein Tyrosine Kinase Collagen Receptor Activity Metal Ion Binding	Pseudophosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity F-box Domain Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Neuromuscular Junction Development Memory Regulation Of Synaptic Growth At Neuromuscular Junction Positive Regulation Of Gene Expression Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Kinase Activity Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Protein Autophosphorylation Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Protein Geranylgeranylation	Protein Dephosphorylation Negative Regulation Of Protein Binding Negative Regulation Of Catalytic Activity MAPK Export From Nucleus Negative Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Regulation Of ERK1 And ERK2 Cascade
Pathways		ECM proteoglycans
Drugs		Fostamatinib
Diseases		Congenital myasthenic syndrome
GWAS		Body mass index ( 28552196) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Pulmonary function decline ( 22424883) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)	Prostate cancer ( 23535732)
Interacting Genes		7 interacting genes: COLQ DOK7 ERBIN ILKAP RAPSN STYX SYNE1	24 interacting genes: AATK CARHSP1 EGFR EPHA2 EPHA3 EPHA7 EPHB6 ERBB2 ERBB3 ERBB4 FBXO7 FBXW7 IGF1R INSR INSRR KDR KIT LMTK2 MAPK1 MUSK PTK7 ROR1 ROR2 TEK
Entrez ID		4593	6815
HPRD ID		03190	10258
Ensembl ID		ENSG00000030304	ENSG00000198252
Uniprot IDs		A0A087WSY1 O15146	A0A024R641 Q8WUJ0
PDB IDs			2R0B
Enriched GO Terms of Interacting Partners?
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